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Figure 9
Schematic diagram of the expected function of ATX-LPA6-Gα13-ROCK axis in CVP formation
LPA produced by ATX activates the LPA6 receptor on endothelial cells, which induces actin stress fiber formation via Gα13, RhoA, and ROCK pathway. Actin stress fiber formation is then stimulated and contributes to (1) activation of Yap transcription factor leading to sprouting angiogenesis via β-catenin and Notch signaling pathways, (2) generation of contractile forces on ECs in developing plexus vessels leading to vessel subdivision and separation.
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