FIGURE

Fig. 8

ID

ZDB-FIG-180516-18

Publication

Ojeda Naharros et al., 2017 - Loss-of-function of the ciliopathy protein Cc2d2a disorganizes the vesicle fusion machinery at the periciliary membrane and indirectly affects Rab8-trafficking in zebrafish photoreceptors

Other Figures

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Fig. 8

SNAP25 mislocalizes in cc2d2a-/- PRs (A-C’) 4 dpf cryosections of wild-type (wt) (A-A’), cc2d2a-/- (B-B’) and ift88-/- (C-C’) retinae stained for SNAP25 (green in A’-C’) and BODIPY (magenta). In wt PRs (A-A’) SNAP25 localizes along the plasma membrane, between the mitochondrial cluster and the OS (arrowhead) and at the synapse. In cc2d2a-/- (B-B’), SNAP25 synaptic localization is preserved but apical mislocalization to a membrane-rich compartment (BODIPY, arrows) is obvious. (C and C’) Despite absence of OSs in the ift88-/- mutant, SNAP25 localizes correctly at the apical membrane of PRs. Scale bars are 10 μm in all panels.

Expression Data

Antibody:	Ab4-snap25
Fish:	WT cc2d2a^w38/w38 ift88^tz288/tz288
Anatomical Terms:	eye photoreceptor cell eye photoreceptor cell apical plasma membrane eye photoreceptor cell synapse
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cc2d2a^w38/w38
Observed In:	eye photoreceptor cell
Stage:	Day 4

Phenotype Detail

Acknowledgments

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