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Fig. 1

ID

ZDB-FIG-180424-50

Publication

Heffer et al., 2017 - Generation and characterization of Kctd15 mutations in zebrafish

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Fig. 1

kctd15 mutants show up-regulation of several NC gene markers.

foxd3 (A-C) and sox10 (D-F) expression is indistinguishable between WT and mutants very early in NC development, but by 3-4s, expression of these markers shows both an expansion and up-regulation in expression, which persists at 8-9s. Other NC markers, including dlx3b (G), sox9b (H), tfap2a (I) and snail1b (J) also show up-regulation and expansion in our mutants at 8-9s. Additionally, an increase in NC cell number is apparent at 24hpf in kctd15 mutants, as visualized in a sox10-GFP reporter construct (K).

Expression Data

Genes:	dlx3b EGFP foxd3 snai1b sox9b sox10 tfap2a (all 7)
Fish:	AB ba2Tg kctd15a^y584/y584; kctd15b^y585/y585 (AB) kctd15a^y584/y584; kctd15b^y585/y585; ba2Tg
Anatomical Terms:	migratory neural crest cell neural crest neural plate border
Stage Range:	1-4 somites to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	kctd15a^y584/y584; kctd15b^y585/y585 (AB) kctd15a^y584/y584; kctd15b^y585/y585; ba2Tg
Observed In:	migratory neural crest cell neural crest neural plate border
Stage Range:	1-4 somites to Prim-5

Phenotype Detail

Acknowledgments

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