Gene
tfap2a
- ID
- ZDB-GENE-011212-6
- Name
- transcription factor AP-2 alpha
- Symbol
- tfap2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within with a positive effect on melanocyte differentiation. Acts upstream of or within several processes, including embryonic organ morphogenesis; nervous system development; and neural crest cell differentiation. Located in nucleus. Is expressed in several structures, including ectoderm; nervous system; neural crest; neural tube; and pronephros. Human ortholog(s) of this gene implicated in branchiooculofacial syndrome. Orthologous to human TFAP2A (transcription factor AP-2 alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 82 figures from 58 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb93 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 44 figures from 18 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| branchiooculofacial syndrome | Alliance | Branchiooculofacial syndrome | 113620 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Transcription factor AP-2 | Transcription factor AP-2 alpha, N-terminal | Transcription factor AP-2, C-terminal |
|---|---|---|---|---|
|
UniProtKB:A0A8M2B9E2
|
457 | |||
|
UniProtKB:F1QUT4
|
437 | |||
|
UniProtKB:A0A2R8QRQ5
|
450 | |||
|
UniProtKB:Q6NYI3
|
425 |
1 - 4 of 4
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tfap2a-201
(1)
|
Ensembl | 2,674 nt | ||
| mRNA |
tfap2a-202
(1)
|
Ensembl | 2,483 nt | ||
| mRNA |
tfap2a-203
(1)
|
Ensembl | 2,458 nt | ||
| mRNA |
tfap2a-204
(1)
|
Ensembl | 2,860 nt | ||
| mRNA |
tfap2a-205
(1)
|
Ensembl | 2,506 nt |
1 - 5 of 6 Show all
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-tfap2a | polyclonal | IgG | Rabbit |
|
AnaSpec
|
2 | |
| Ab2-tfap2a | polyclonal | Goat |
|
LifeSpan BioSciences, Inc.
|
4 |
1 - 2 of 2
Plasmids
No data available