Gene

tfap2a

ID

ZDB-GENE-011212-6

Name

transcription factor AP-2 alpha

Symbol

tfap2a Nomenclature History

Previous Names

ap2 (1)
ap2a (1)
cb93 (1)
fb83f04
fc31a07 (1)
lockjaw
low
mob (1)
mont blanc (1)
wu:fb83f04 (1)
wu:fc31a07 (1)

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; iridophore differentiation; and nervous system development. Localizes to nucleus. Human ortholog(s) of this gene implicated in branchiooculofacial syndrome. Is expressed in several structures, including ectoderm; nervous system; neural crest; neural tube; and pronephros. Orthologous to human TFAP2A (transcription factor AP-2 alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

82 figures from 58 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb93 (19 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 44 figures from 18 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tfap2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
branchiooculofacial syndrome	Alliance	Branchiooculofacial syndrome	113620

Associated With tfap2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR008121	Transcription factor AP-2 alpha, N-terminal
Domain	IPR013854	Transcription factor AP-2, C-terminal
Family	IPR004979	Transcription factor AP-2

Domain Details Per Protein

Protein	Length	Transcription factor AP-2	Transcription factor AP-2 alpha, N-terminal	Transcription factor AP-2, C-terminal
UniProtKB:A0A8M2B9E2 InterPro	457
UniProtKB:F1QUT4 InterPro	437
UniProtKB:A0A2R8QRQ5 InterPro	450
UniProtKB:Q6NYI3 InterPro	425

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tfap2a-201 (1) Ensembl	Ensembl	2,674 nt	Select Tool ZFIN BLAST
mRNA	tfap2a-202 (1) Ensembl	Ensembl	2,483 nt	Select Tool ZFIN BLAST
mRNA	tfap2a-203 (1) Ensembl	Ensembl	2,458 nt	Select Tool ZFIN BLAST
mRNA	tfap2a-204 (1) Ensembl	Ensembl	2,860 nt	Select Tool ZFIN BLAST
mRNA	tfap2a-205 (1) Ensembl	Ensembl	2,506 nt	Select Tool ZFIN BLAST
mRNA	tfap2a-206 (1) Ensembl	Ensembl	1,311 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-tfap2a	polyclonal	tfap2a	IgG	Rabbit	IHC	AnaSpec	2
Ab2-tfap2a	polyclonal	tfap2a		Goat	IHC	LifeSpan BioSciences, Inc.	4

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations