Gene

dlx3b

ID
ZDB-GENE-980526-280
Name
distal-less homeobox 3b
Symbol
dlx3b Nomenclature History
Previous Names
  • dlx-3
  • dlx3
  • id:ibd3531 (1)
  • wu:fb83f11
  • zgc:91827
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Exhibits sequence-specific DNA binding activity. Involved in several processes, including sensory organ development; skeletal system development; and trigeminal nerve development. Predicted to localize to nuclear chromatin. Is expressed in several structures, including ectoderm; neural plate; neurogenic field; pharyngeal arch; and presumptive structure. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 4 and trichodontoosseous syndrome. Orthologous to human DLX3 (distal-less homeobox 3).
Genome Resources
Note
None
Expression
All Expression Data
247 figures from 166 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dlx3b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
amelogenesis imperfecta type 4 Alliance Amelogenesis imperfecta, type IV 104510
trichodontoosseous syndrome Alliance Trichodontoosseous syndrome 190320
Associated With dlx3b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR000047 Helix-turn-helix motif
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR020479 Homeobox domain, metazoa
Domain IPR022135 Distal-less-like homeobox protein, N-terminal domain
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Distal-less-like homeobox protein, N-terminal domain Helix-turn-helix motif Homeobox, conserved site Homeobox domain Homeobox domain, metazoa Homeobox-like domain superfamily
UniProtKB:Q01702 269
UniProtKB:Q6DBS2 269
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations