ZFIN ID: ZDB-GENE-980526-514
Gene Name: snail family zinc finger 1b
Gene Symbol: snai1b    Nomenclature History

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Previous Names: sna2, snail-2 (1), snail1b (1), snail2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including ameboidal-type cell migration; cardiac muscle progenitor cell migration to the midline involved in heart field formation; and posterior lateral line neuromast primordium migration. Predicted to localize to the nucleus. Is expressed in several structures, including ectoderm; heart; mesoderm; neural crest; and trunk. Orthologous to human SNAI1 (snail family transcriptional repressor 1).
Genome Resources: Alliance (1),  Gene:792194 (1),  Ensembl(GRCz11):ENSDARG00000046019 (1)
Note: This gene was originally named snail2 (Thisse et al. 1993). In 2004 Manzanares et al. demonstrated that this gene arose from a duplication event in the teleost lineage that resulted in snail1a and snail1b resulting in a gene name change.
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12537 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12547 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19312 Point Mutation Unknown Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-snai1b N/A 4
    MO2-snai1b N/A 2
    MO3-snai1b N/A 1
    MO4-snai1b N/A 1
    DISEASE ASSOCIATED WITH snai1b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH snai1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process posterior lateral line neuromast primordium migration (more)
    Cellular Component nucleus (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR013087 Zinc finger C2H2-type
    Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM snai1b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(snai1b:EGFP) snai1b EGFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    snai1b Encodes: [cDNA] MGC:193979 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130989 (1) 915 bp
    Genomic GenBank:LO017827 (1)
    Polypeptide UniProtKB:Q90414 (1) 257 aa
    Sequence Information (all 14)
    ORTHOLOGY for snai1b ( Chr: 23 )
    CITATIONS (122)