FIGURE

Fig. 3

ID

ZDB-FIG-150504-19

Publication

Kantarci et al., 2015 - Tfap2a Promotes Specification and Maturation of Neurons in the Inner Ear through Modulation of Bmp, Fgf and Notch Signaling

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Fig. 3

Tfap2a regulates the number of transit-amplifying SAG precursors.

(A-I) Cross-sections (medial left, dorsal up) at the level of the utricular macula showing neurod expression in +/+ control, tfap2a mutants and hs:tfap2a embryos. Wild-type and hs:tfap2a embryos were heat shocked at 24 hpf. Disruption of tfap2a leads to accumulation of excess TA cells whereas tfap2a overexpression decreases the number of the TA cells. The outer and inner edges of the otic vesicle are outlined in each image. (J) Mean and standard deviation of the total number of neurod positive SAG precursors for the genotypes and conditions indicated in the color key (counted from serial sections, n = 3–6 ears per time point). Asterisks (*) indicate significant differences from control specimens.

Expression Data

Gene:	neurod1
Fish:	AB tfap2a^m819/m819 x24Tg
Condition:	heat shock
Anatomical Term:	statoacoustic (VIII) ganglion neuroblast (sensu Vertebrata)
Stage Range:	Prim-15 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tfap2a^m819/m819 x24Tg
Condition:	heat shock
Observed In:	statoacoustic (VIII) ganglion statoacoustic (VIII) ganglion neuroblast (sensu Vertebrata)
Stage Range:	Prim-15 to Long-pec

Phenotype Detail

Acknowledgments

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