ZFIN ID: ZDB-FIG-150504-19
Kantarci et al., 2015 - Tfap2a Promotes Specification and Maturation of Neurons in the Inner Ear through Modulation of Bmp, Fgf and Notch Signaling. PLoS Genetics   11:e1005037 Full text @ PLoS Genet.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Gene:
Fish:
Condition:
Anatomical Term:
Stage Range: Prim-15 to Long-pec
PHENOTYPE:
Fish:
Condition:
Observed In:
Stage Range: Prim-15 to Long-pec

Fig. 3 Tfap2a regulates the number of transit-amplifying SAG precursors.

(A-I) Cross-sections (medial left, dorsal up) at the level of the utricular macula showing neurod expression in +/+ control, tfap2a mutants and hs:tfap2a embryos. Wild-type and hs:tfap2a embryos were heat shocked at 24 hpf. Disruption of tfap2a leads to accumulation of excess TA cells whereas tfap2a overexpression decreases the number of the TA cells. The outer and inner edges of the otic vesicle are outlined in each image. (J) Mean and standard deviation of the total number of neurod positive SAG precursors for the genotypes and conditions indicated in the color key (counted from serial sections, n = 3–6 ears per time point). Asterisks (*) indicate significant differences from control specimens.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
neurod1 AB heat shock Prim-15 statoacoustic (VIII) ganglion neuroblast (sensu Vertebrata) ISH
Prim-25 statoacoustic (VIII) ganglion neuroblast (sensu Vertebrata) ISH
Long-pec statoacoustic (VIII) ganglion neuroblast (sensu Vertebrata) ISH
tfap2am819/m819 standard conditions Prim-15 statoacoustic (VIII) ganglion neuroblast (sensu Vertebrata) ISH
Prim-25 statoacoustic (VIII) ganglion neuroblast (sensu Vertebrata) ISH
Long-pec statoacoustic (VIII) ganglion neuroblast (sensu Vertebrata) ISH
x24Tg heat shock Prim-15 statoacoustic (VIII) ganglion neuroblast (sensu Vertebrata) ISH
Prim-25 statoacoustic (VIII) ganglion neuroblast (sensu Vertebrata) ISH
Long-pec statoacoustic (VIII) ganglion neuroblast (sensu Vertebrata) ISH
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
tfap2am819/m819 standard conditions Prim-15 statoacoustic (VIII) ganglion has extra parts of type statoacoustic (VIII) ganglion neuroblast (sensu Vertebrata), abnormal
Prim-25 statoacoustic (VIII) ganglion has extra parts of type statoacoustic (VIII) ganglion neuroblast (sensu Vertebrata), abnormal
Long-pec statoacoustic (VIII) ganglion has extra parts of type statoacoustic (VIII) ganglion neuroblast (sensu Vertebrata), abnormal
x24Tg heat shock Prim-15 statoacoustic (VIII) ganglion has fewer parts of type statoacoustic (VIII) ganglion neuroblast (sensu Vertebrata), abnormal
Prim-25 statoacoustic (VIII) ganglion has fewer parts of type statoacoustic (VIII) ganglion neuroblast (sensu Vertebrata), abnormal
Long-pec statoacoustic (VIII) ganglion has fewer parts of type statoacoustic (VIII) ganglion neuroblast (sensu Vertebrata), abnormal
Acknowledgments:
ZFIN wishes to thank the journal PLoS Genetics for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ PLoS Genet.