FIGURE

Fig. 1

ID

ZDB-FIG-140822-58

Publication

Rost et al., 2014 - Hyaluronic acid receptor Stabilin-2 regulates Erk phosphorylation and arterial--venous differentiation in zebrafish

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Fig. 1

Stab2 morphants display a lack of intersegmental vessels.

(A–H) In situ hybridization analysis shows a lack of ISVs in Stab2 morphants as observed by endothelial marker fli1a (A and B), kdrl (C and D), esam (E and F), and she (G and H) expression at 24 hpf, as compared to uninjected controls. Arrows indicate ISVs in control embryos and missing ISVs in morphants. Arrowheads indicate stronger PCV expression of kdrl and esam in morphant embryos (D and F). Lateral view, anterior is to the left; trunk and tail region is shown. Morphants were injected with a cocktail containing Stab2 MO1 and MO2, as well as p53 MO. ISVs: intersegmental vessels; PCV: posterior cardinal vein.

Expression Data

Genes:	esama fli1 kdrl she
Fish:	WT WT + MO1-stab2 + MO4-stab2 + MO4-tp53
Knockdown Reagents:	MO1-stab2 MO4-stab2 MO4-tp53
Anatomical Terms:	intersegmental vessel posterior cardinal vein
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-stab2 + MO4-stab2 + MO4-tp53
Knockdown Reagents:	MO1-stab2 MO4-stab2 MO4-tp53
Observed In:	intersegmental vessel
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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