FIGURE

Fig. 4

ID

ZDB-FIG-140211-9

Publication

Breau et al., 2013 - A Hox gene controls lateral line cell migration by regulating chemokine receptor expression downstream of Wnt signaling

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Fig. 4

Dominant activator Hoxb8a activates cxcr4b expression and down-regulates cxcr7b. (A) Fluorescent images of cldnb:lyngfp in cldnb4.2:gal4 x UAS:Hoxb8aVP16 embryos and control siblings at 45 hpf. Blue arrow shows the morphological eye defect observed in all Hoxb8aVP16 embryos. Red arrowheads indicate the position of the primordium. (B) Quantification of the migration at 45 hpf (control, n = 50; cldnb4.2:gal4 x UAS:Hoxb8aVP16, n = 56). ISH showing expression of (C) cxcr4b, (D) cxcr7b, and (E) lef1 in cldnb4.2:gal4 x UAS:Hoxb8aVP16 and control siblings at 28 hpf. (Scale bar: 25 µm.)

Expression Data

Genes:	ackr3b cxcr4b EGFP lef1
Fish:	zf106Tg nim11Tg; nim14Tg; zf106Tg
Anatomical Terms:	posterior lateral line primordium posterior lateral line primordium posterior-most region
Stage Range:	Prim-5 to High-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nim11Tg; nim14Tg; zf106Tg
Observed In:	posterior lateral line neuromast primordium migration
Stage:	High-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA