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Fig. 4
Dominant activator Hoxb8a activates cxcr4b expression and down-regulates cxcr7b. (A) Fluorescent images of cldnb:lyngfp in cldnb4.2:gal4 x UAS:Hoxb8aVP16 embryos and control siblings at 45 hpf. Blue arrow shows the morphological eye defect observed in all Hoxb8aVP16 embryos. Red arrowheads indicate the position of the primordium. (B) Quantification of the migration at 45 hpf (control, n = 50; cldnb4.2:gal4 x UAS:Hoxb8aVP16, n = 56). ISH showing expression of (C) cxcr4b, (D) cxcr7b, and (E) lef1 in cldnb4.2:gal4 x UAS:Hoxb8aVP16 and control siblings at 28 hpf. (Scale bar: 25 µm.)
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