FIGURE

Fig. 6

ID

ZDB-FIG-131231-42

Publication

van der Velden et al., 2013 - The polycomb group protein ring1b/rnf2 is specifically required for craniofacial development

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Fig. 6

Loss of endochondral and dermal ossification in ring1b mutants.

Ventral (A–D, E, F) and lateral (A′–D′, E′,) views of in situ hybridizations with riboprobes against the indicated genes in WT and ring1b mutants at 68–72 hpf. In WT embryos, runx2a and runx2b are expressed in hypertrophic pharyngeal arch-derived chondrocytes, as well as in the dermal ossification centers of the operculum, parasphenoid and cleithrum. Weak expression is detected in pharyngeal arches and the parasphenoid of ring1b mutants (B, B′, D, D′). At 72 hpf, col10a1 is expressed in developing dermal bones in WT embryos, but not in ring1b mutants (E–F). cl: cleithrum; de: dentary; h: hyoid; m: mandibular; mx: maxilla; pa: pharyngeal arches; pq: palatoquadrate; ps: parasphenoid, op: operculum cl: the cleithrum. Numbers indicate the respective pharyngeal arches.

Expression Data

Genes:	col10a1a runx2a runx2b
Fish:	WT rnf2^ibl30/ibl30 rnf2^ibl31/ibl31
Anatomical Terms:	branchiostegal ray cleithrum dentary maxilla opercle parasphenoid pharyngeal arch pharyngeal arch hypertrophic chondrocyte
Stage Range:	Pec-fin to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	rnf2^ibl30/ibl30 rnf2^ibl31/ibl31
Observed In:	cleithrum direct ossification endochondral ossification opercle parasphenoid pharyngeal arch cartilage
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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