FIGURE

Fig. 7

ID

ZDB-FIG-130809-1

Publication

Shin et al., 2012 - Intrinsic and extrinsic modifiers of the regulative capacity of the developing liver

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Fig. 7

Hepatic sox17 and sox32 expression in wnt2bb mutant and Wnt/β-catenin signaling deficient embryos lacking Fgf10a function. (A-F) Hepatic sox17 expression was present in Wnt/β-catenin signaling deficient embryos treated with SU5402 (1 µM) from 30 to 44 hpf (B) as well as in Wnt/β-catenin signaling deficient embryos lacking Fgf10a function (D). Hepatic sox32 expression was also present in these embryos (F). Dorsal views, anterior to the left. (G-J) There was no clear difference in the hepatic sox17 expression domain among wild-type, fgf10a^-/- and wnt2bb^-/- embryos (G-I). However, it expanded into the extrahepatic duct region in most fgf10a^-/-;wnt2bb^-/- (J, five out of seven embryos). Dorsal views, anterior up. Scale bars, 100 µm.

Expression Data

Genes:	sox17 sox32
Fish:	WT fgf10a^tbvbo/tbvbo wnt2bb^s403/s403 fgf10a^tbvbo/tbvbo; wnt2bb^s403/s403 wnt2bb^s403/s403; w32Tg fgf10a^tbvbo/tbvbo; wnt2bb^s403/s403; w32Tg
Conditions:	heat shock chemical treatment: SU5402, heat shock
Anatomical Terms:	hepatic duct liver
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fgf10a^tbvbo/tbvbo wnt2bb^s403/s403 fgf10a^tbvbo/tbvbo; wnt2bb^s403/s403 wnt2bb^s403/s403; w32Tg fgf10a^tbvbo/tbvbo; wnt2bb^s403/s403; w32Tg
Condition:	heat shock
Observed In:	extrahepatic duct gallbladder development hepatic duct development liver liver development
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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Reprinted from Mechanisms of Development, 128(11-12), Shin, D., Weidinger, G., Moon, R.T., and Stainier, D.Y., Intrinsic and extrinsic modifiers of the regulative capacity of the developing liver, 525-535, Copyright (2012) with permission from Elsevier. Full text @ Mech. Dev.