Gene

sox17

ID
ZDB-GENE-991213-1
Name
SRY-box transcription factor 17
Symbol
sox17 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in Kupffer's vesicle development; determination of left/right symmetry; and primitive hemopoiesis. Predicted to localize to nuclear chromatin. Is expressed in several structures, including Kupffer's vesicle; endoderm; lateral plate mesoderm; liver and biliary system; and presumptive structure. Human ortholog(s) of this gene implicated in vesicoureteral reflux. Orthologous to human SOX17 (SRY-box transcription factor 17).
Genome Resources
Note
None
Expression
All Expression Data
154 figures from 105 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sox17 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
vesicoureteral reflux Alliance Vesicoureteral reflux 3 613674
Associated With sox17 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR009071 High mobility group box domain
Domain IPR033392 Sox 7/17/18, central domain
Homologous_superfamily IPR036910 High mobility group box domain superfamily
Domain Details Per Protein
Protein Length High mobility group box domain High mobility group box domain superfamily Sox 7/17/18, central domain
UniProtKB:Q5PQZ5 413
UniProtKB:Q9PTN0 413
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations