FIGURE

Fig. 4

ID

ZDB-FIG-130730-4

Publication

Wilfinger et al., 2013 - Cell type and tissue specific function of islet genes in zebrafish pancreas development

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Fig. 4

isl2a does not contribute to endocrine cell formation. (A–C) Immunostainings for Ins (green) and Isl-proteins (red) in the pancreatic region of control (A), isl1 mutant (B), and isl1 mutant/MO^isl2a injected embryos (C) at 48 hpf. (D) Quantification of ins mRNA positive cells and examples of corresponding in situ stains for ins mRNA in isl1 mutants (E, G), and in isl1 mutant, MO^isl2a injected embryos (F, H) at 30 hpf (E, F) and 72 hpf (G, H). Bars show mean+SEM.

Expression Data

Gene:	ins
Antibodies:	Ab1-ins Ab2-isl
Fish:	WT isl1a^sa29/sa29 isl1a^sa29/sa29 + MO3-isl2a
Knockdown Reagent:	MO3-isl2a
Anatomical Terms:	endocrine pancreas endocrine pancreas insulin secreting cell mesenchyme pancreatic system mesenchyme posterior pancreatic bud insulin secreting cell
Stage Range:	Prim-15 to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 378(1), Wilfinger, A., Arkhipova, V., and Meyer, D., Cell type and tissue specific function of islet genes in zebrafish pancreas development, 25-37, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.