ZFIN ID: ZDB-FIG-130322-12
Clements et al., 2011 - A somitic Wnt16/Notch pathway specifies haematopoietic stem cells. Nature   474(7350):220-224 Full text @ Nature
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Knockdown Reagents:
Anatomical Terms:
Stage Range: 14-19 somites to Day 4
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage Range: 14-19 somites to Day 4

Fig. 3 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Qualifier Anatomy Assay
dlc WT standard conditions 14-19 somites segmental plate ISH
14-19 somites tail bud ISH
WT + MO1-wnt16 + MO2-wnt16 standard conditions 14-19 somites segmental plate ISH
14-19 somites Not Detected somite ISH
14-19 somites tail bud ISH
dld WT standard conditions 14-19 somites segmental plate ISH
14-19 somites tail bud ISH
WT + MO1-wnt16 + MO2-wnt16 standard conditions 14-19 somites segmental plate ISH
14-19 somites Not Detected somite ISH
14-19 somites tail bud ISH
myb WT control Prim-25 ventral wall of dorsal aorta hematopoietic stem cell ISH
WT + MO2-dld standard conditions Prim-25 ventral wall of dorsal aorta hematopoietic stem cell ISH
dlctit446/tit446 standard conditions Prim-25 ventral wall of dorsal aorta hematopoietic stem cell ISH
dlctit446/tit446 + MO2-dld standard conditions Prim-25 Not Detected ventral wall of dorsal aorta hematopoietic stem cell ISH
rag1 WT control Day 4 thymus T cell ISH
WT + MO2-dld standard conditions Day 4 thymus T cell ISH
dlctit446/tit446 standard conditions Day 4 thymus T cell ISH
dlctit446/tit446 + MO2-dld standard conditions Day 4 Not Detected thymus T cell ISH
runx1 WT control Prim-5 ventral wall of dorsal aorta hematopoietic stem cell ISH
WT + MO2-dld standard conditions Prim-5 ventral wall of dorsal aorta hematopoietic stem cell ISH
dlctit446/tit446 standard conditions Prim-5 ventral wall of dorsal aorta hematopoietic stem cell ISH
dlctit446/tit446 + MO2-dld standard conditions Prim-5 Not Detected ventral wall of dorsal aorta hematopoietic stem cell ISH
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO1-wnt16 + MO2-wnt16 standard conditions 14-19 somites hematopoietic stem cell differentiation disrupted, abnormal
14-19 somites Notch signaling pathway disrupted, abnormal
WT + MO2-dld standard conditions Prim-5 hematopoietic stem cell decreased amount, abnormal
Prim-5 hematopoietic stem cell differentiation disrupted, abnormal
Prim-25 hematopoietic stem cell decreased amount, abnormal
Prim-25 hematopoietic stem cell differentiation disrupted, abnormal
Day 4 thymus T cell normal amount, normal
dlctit446/tit446 standard conditions Prim-5 hematopoietic stem cell decreased amount, abnormal
Prim-5 hematopoietic stem cell differentiation disrupted, abnormal
Prim-25 hematopoietic stem cell decreased amount, abnormal
Prim-25 hematopoietic stem cell differentiation disrupted, abnormal
Day 4 thymus T cell normal amount, normal
dlctit446/tit446 + MO2-dld standard conditions Prim-5 hematopoietic stem cell absent, abnormal
Prim-5 hematopoietic stem cell differentiation disrupted, abnormal
Prim-25 hematopoietic stem cell absent, abnormal
Prim-25 hematopoietic stem cell differentiation disrupted, abnormal
Day 4 hematopoietic stem cell differentiation disrupted, abnormal
Day 4 thymus T cell absent, abnormal
Full text @ Nature