Gene
dlc
- ID
- ZDB-GENE-000125-4
- Name
- deltaC
- Symbol
- dlc Nomenclature History
- Previous Names
-
- bea
- beamter
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Enables PDZ domain binding activity and identical protein binding activity. Involved in negative regulation of Notch signaling pathway. Acts upstream of or within several processes, including blood vessel development; neuron differentiation; and somite development. Located in perinuclear region of cytoplasm and plasma membrane. Is expressed in several structures, including immature eye; integument; mesoderm; nervous system; and trunk. Human ortholog(s) of this gene implicated in dysostosis and spondylocostal dysostosis. Orthologous to human DLL1 (delta like canonical Notch ligand 1) and DLL3 (delta like canonical Notch ligand 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 166 figures from 102 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d401 (20 images)
- eu289 (26 images)
- eu238 (18 images)
Wild Type Expression Summary
- All Phenotype Data
- 18 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spondylocostal dysostosis 1 | Alliance | Spondylocostal dysostosis 1, autosomal recessive | 277300 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR013032 | EGF-like, conserved site |
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001774 | Delta/Serrate/lag-2 (DSL) protein |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Domain Details Per Protein
| Protein | Length | Delta/Serrate/lag-2 (DSL) protein | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B3DFM3
|
664 | |||||||
|
UniProtKB:A0A2R8QUE3
|
677 | |||||||
|
UniProtKB:Q9IAT6
|
664 | |||||||
|
UniProtKB:A4JYS0
|
664 |
Interactions and Pathways
Plasmids
No data available