ZFIN ID: ZDB-GENE-000125-4
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Gene Name: deltaC
Gene Symbol: dlc    Nomenclature History

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Previous Names: bea, beamter

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Exhibits PDZ domain binding activity and identical protein binding activity. Involved in several processes, including blood vessel development; neuron differentiation; and somite development. Localizes to the perinuclear region of cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in dysostosis and spondylocostal dysostosis. Is expressed in several structures, including immature eye; integument; mesoderm; nervous system; and trunk. Orthologous to human DLL3 (delta like canonical Notch ligand 3).
Genome Resources: Alliance (1),  Gene:30120 (1),  Ensembl(GRCz11):ENSDARG00000002336 (1)
GENE EXPRESSION
All Expression Data: 149 figures from 94 publications
Directly Submitted Expression Data: 6 figures (20 images) from Thisse et al., 2008 [cssl:d401]
  6 figures (26 images) from Thisse et al., 2005 [eu289]
  6 figures (18 images) from Thisse et al., 2005 [eu238]
Wild-type Stages, Structures: Blastula:30%-epiboly (4.66h-5.25h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b663 Unknown Unknown Unknown
dlc_unspecified Unspecified Unknown Unknown
la012690Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa35867 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa42530 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • thf102 Small Deletion Unknown Unknown
    tit446 Point Mutation Unknown Unknown
  • Zebrafish International Resource Center (ZIRC) (order this)
    • tm98 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
    • to202 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
    • tw212b Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
    • y56 Point Mutation Unknown Unknown ENU
    y70 Unknown Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dlc N/A 4
    MO2-dlc N/A 4
    MO3-dlc N/A 1
    MO4-dlc N/A 1
    MO5-dlc N/A 2
    MO6-dlc N/A 1
    MO7-dlc N/A 1
    MO8-dlc N/A 1
    MO9-dlc N/A 1
    PHENOTYPE
    Data: 18 figures from 9 publications
    Observed in:
    DISEASE ASSOCIATED WITH dlc HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    spondylocostal dysostosis Alliance Spondylocostal dysostosis 1, autosomal recessive 277300
    DISEASE ASSOCIATED WITH dlc VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dorsal aorta development (more)
    Cellular Component cytoplasm (more)
    Molecular Function identical protein binding (more)
    GO Terms (all 24)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
    Domain IPR000742 EGF-like domain
    Domain IPR001774 Delta/Serrate/lag-2 (DSL) protein
    Domain IPR001881 EGF-like calcium-binding domain
    Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
    Conserved_site IPR013032 EGF-like, conserved site
    Conserved_site IPR018097 EGF-like calcium-binding, conserved site
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dlc-201 (1)    Ensembl 3567
    Select Tool
    ncRNA dlc-002 (1)    Ensembl 728
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dlc
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(dlc:mcherry) dlc mCherry Danio rerio 1 1
    Tg(hsp70l:dlc) hsp70l dlc Danio rerio 1 3
    Tg(mitfa:dlc) mitfa dlc Danio rerio 1 3
    Tg(UAS:dlc) dlc Danio rerio 1 2
    tg2(dlc:mcherry) dlc mCherry Danio rerio 1 1
    tg3(dlc:mcherry) dlc mCherry Danio rerio 1 1
    MARKER RELATIONSHIPS
    dlc Contained in: [BAC] DKEY-46I14 (1) (order this)
    dlc Encodes: [EST] eu238 (1), eu289 (1)
    [cDNA] cssl:d401 (1), MGC:193544 (1), MGC:193551 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130944 (1) 3610 bp
    Select Tool
    Genomic GenBank:CR626887 (1) 198090 bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8QUE3 (1) 677 aa
    Select Tool
    Sequence Information (all 27)
    ORTHOLOGY for dlc ( Chr: 15 )
    CITATIONS (245)