|ZFIN ID: ZDB-FIG-100427-28|
|Stage Range:||Prim-5 to Prim-15|
Fig. 4 Effects of nkx6 knockdown on endocrine cells. A–P: Ventral views of WISHs showing expression of glucagon at 30 hpf (A, E, I and M), insulin at 24 hpf (B, F, J and N), somatostatin at 24 hpf (C, G, K and O), and ghrelin at 30 hpf (D, H, L and P) in control (A–D), nkx6.1 (E–H), nkx6.2 (I–L), and nkx6.1/nkx6.2 (M–P) morphants. Scale: 20 μm. Q–S: Number of cells expressing glucagon at 30 hpf in nkx6.1 (Q) and nkx6.2 (R) morphants (the horizontal line represents the mean) and number of cells expressing the different pancreatic hormones at 30 hpf in nkx6.1/nkx6.2 morphants (S). The presented data are representative of at least three reproducible and independent experiments.
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Reprinted from Developmental Biology, 340(2), Binot, A.C., Manfroid, I., Flasse, L., Winandy, M., Motte, P., Martial, J.A., Peers, B., and Voz, M.L., Nkx6.1 and nkx6.2 regulate alpha- and beta-cell formation in zebrafish by acting on pancreatic endocrine progenitor cells, 397-407, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.