ZFIN Morpholino: MO1-nkx6.1

Target Location

Genome Build: GRCz11Chromosome: 21

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-nkx6.1

Expressed Gene	Anatomy	Figures
alcama	spinal cord secondary motor neuron	Fig. 8 from Cheesman et al., 2004
isl1a	primary motor neuron Rohon-Beard neuron	Fig. 2 from Hutchinson et al., 2007 Fig. 8 from Cheesman et al., 2004
isl2a	CaP motoneuron Rohon-Beard neuron	Fig. 2 from Hutchinson et al., 2007

Phenotype

Phenotype resulting from MO1-nkx6.1

Phenotype	Fish	Figures
neuron fate commitment disrupted, abnormal	AB + MO1-nkx6.1	Fig. 8 from Cheesman et al., 2004
primary motor neuron axon branched, abnormal	AB + MO1-nkx6.1	Fig. 3 from Hutchinson et al., 2007
primary motor neuron axon decreased amount, abnormal	AB + MO1-nkx6.1	Fig. 3 from Hutchinson et al., 2007
primary motor neuron axon decreased length, abnormal	AB + MO1-nkx6.1	Fig. 3 from Hutchinson et al., 2007
secondary motor neuron decreased amount, abnormal	AB + MO1-nkx6.1	Fig. 8 from Cheesman et al., 2004
VeLD increased amount, abnormal	AB + MO1-nkx6.1	Fig. 8 from Cheesman et al., 2004

Phenotype of all Fish created by or utilizing MO1-nkx6.1

Phenotype	Fish	Conditions	Figures
primary motor neuron axon decreased amount, abnormal	AB + MO1-nkx6.1	standard conditions	Fig. 3 from Hutchinson et al., 2007
primary motor neuron axon branched, abnormal	AB + MO1-nkx6.1	standard conditions	Fig. 3 from Hutchinson et al., 2007
neuron fate commitment disrupted, abnormal	AB + MO1-nkx6.1	standard conditions	Fig. 8 from Cheesman et al., 2004
primary motor neuron axon decreased length, abnormal	AB + MO1-nkx6.1	standard conditions	Fig. 3 from Hutchinson et al., 2007
VeLD increased amount, abnormal	AB + MO1-nkx6.1	standard conditions	Fig. 8 from Cheesman et al., 2004
secondary motor neuron decreased amount, abnormal	AB + MO1-nkx6.1	standard conditions	Fig. 8 from Cheesman et al., 2004
pancreatic bud has fewer parts of type pancreatic A cell, abnormal	AB + MO1-nkx6.1 + MO2-nkx6.1	standard conditions	Fig. 4 from Binot et al., 2010
pancreas primordium has fewer parts of type endocrine cell, abnormal	AB + MO1-nkx6.1 + MO2-nkx6.1	standard conditions	Fig. 7 , Fig. 8 from Binot et al., 2010
pancreatic bud has fewer parts of type endocrine cell, abnormal	AB + MO1-nkx6.1 + MO2-nkx6.1	standard conditions	Fig. 7 from Binot et al., 2010
primary motor neuron axon decreased length, abnormal	AB + MO1-nkx6.1 + MO1-nkx6.2	standard conditions	Fig. 3 , Fig. 4 from Hutchinson et al., 2007
primary motor neuron axon decreased amount, abnormal	AB + MO1-nkx6.1 + MO1-nkx6.2	standard conditions	Fig. 3 from Hutchinson et al., 2007
primary motor neuron axon branched, abnormal	AB + MO1-nkx6.1 + MO1-nkx6.2	standard conditions	Fig. 3 , Fig. 4 from Hutchinson et al., 2007
primary motor neuron axon structure, abnormal	AB + MO1-nkx6.1 + MO1-nkx6.2	standard conditions	Fig. 4 from Hutchinson et al., 2007

Citations

Include unpublished citations

Seredick, S., Van Ryswyk, L., Hutchinson, S.A., and Eisen, J.S. (2012) Zebrafish Mnx proteins specify one motoneuron subtype and suppress acquisition of interneuron characteristics. Neural Development. 7(1):35
Binot, A.C., Manfroid, I., Flasse, L., Winandy, M., Motte, P., Martial, J.A., Peers, B., and Voz, M.L. (2010) Nkx6.1 and nkx6.2 regulate alpha- and beta-cell formation in zebrafish by acting on pancreatic endocrine progenitor cells. Developmental Biology. 340(2):397-407
Hutchinson, S.A., Cheesman, S.E., Hale, L.A., Boone, J.Q., and Eisen, J.S. (2007) Nkx6 proteins specify one zebrafish primary motoneuron subtype by regulating late islet1 expression. Development (Cambridge, England). 134(9):1671-1677
Cheesman, S.E., Layden, M.J., Von Ohlen, T., Doe, C.Q., and Eisen, J.S. (2004) Zebrafish and fly Nkx6 proteins have similar CNS expression patterns and regulate motoneuron formation. Development (Cambridge, England). 131(21):5221-5232

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