FIGURE

Fig. 1

ID

ZDB-FIG-090831-36

Publication

French et al., 2009 - Gdf6a is required for the initiation of dorsal-ventral retinal patterning and lens development

Other Figures

(all 11)

All Figure Page

Back to All Figure Page

Fig. 1

Loss of dorsal signaling and expansion of ventral gene expression in gdf6a morphants. The phosphorylation of Smad 1/5/8 proteins is found in the dorsal retina and lens (A) and is lost in gdf6a morphants (B). The expression of dorsal markers tbx5, aldh1a2, bambi, (C, E, G) are lost in gdf6a morphants (D, F, H). The expression of the ventral specific vax2 (I) and is expanded throughout the retina in gdf6a morphants (J). The expression of the ventral specific aldh1a3 is found also in the ventral retina (K), and is expanded in gdf6a morphants (L). All embryos were staged to 28 hpf.

Expression Data

Genes:	aldh1a2 aldh1a3 bambia tbx5a vax2
Antibody:	Ab1-smad
Fish:	WT WT + MO1-gdf6a + MO4-tp53
Knockdown Reagents:	MO1-gdf6a MO4-tp53
Anatomical Terms:	optic cup optic cup dorsal region optic cup ventral region solid lens vesicle
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 333(1), French, C.R., Erickson, T., French, D.V., Pilgrim, D.B., and Waskiewicz, A.J., Gdf6a is required for the initiation of dorsal-ventral retinal patterning and lens development, 37-47, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.