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Fig. 1
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Fig. 1 Loss of dorsal signaling and expansion of ventral gene expression in gdf6a morphants. The phosphorylation of Smad 1/5/8 proteins is found in the dorsal retina and lens (A) and is lost in gdf6a morphants (B). The expression of dorsal markers tbx5, aldh1a2, bambi, (C, E, G) are lost in gdf6a morphants (D, F, H). The expression of the ventral specific vax2 (I) and is expanded throughout the retina in gdf6a morphants (J). The expression of the ventral specific aldh1a3 is found also in the ventral retina (K), and is expanded in gdf6a morphants (L). All embryos were staged to 28 hpf.
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Reprinted from Developmental Biology, 333(1), French, C.R., Erickson, T., French, D.V., Pilgrim, D.B., and Waskiewicz, A.J., Gdf6a is required for the initiation of dorsal-ventral retinal patterning and lens development, 37-47, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.