Gene

aldh1a2

ID

ZDB-GENE-011010-3

Name

aldehyde dehydrogenase 1 family, member A2

Symbol

aldh1a2 Nomenclature History

Previous Names

raldh2 (1)
neckless
nls
no-fin (1)
nof (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have aldehyde dehydrogenase (NAD+) activity. Involved in several processes, including animal organ development; face morphogenesis; and myelination. Is expressed in several structures, including head; heart; immature eye; mesoderm; and pleuroperitoneal region. Orthologous to human ALDH1A2 (aldehyde dehydrogenase 1 family member A2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

135 figures from 103 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 40 figures from 24 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With aldh1a2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Diaphragmatic hernia 4, with cardiovascular defects	620025

Associated With aldh1a2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR016160	Aldehyde dehydrogenase, cysteine active site
Conserved_site	IPR029510	Aldehyde dehydrogenase, glutamic acid active site
Domain	IPR015590	Aldehyde dehydrogenase domain
Homologous_superfamily	IPR016161	Aldehyde/histidinol dehydrogenase
Homologous_superfamily	IPR016162	Aldehyde dehydrogenase, N-terminal
Homologous_superfamily	IPR016163	Aldehyde dehydrogenase, C-terminal