FIGURE

Fig. 2

ID

ZDB-FIG-090113-97

Publication

Chakraborty et al., 2009 - Loss of ribosomal protein L11 affects zebrafish embryonic development through a p53-dependent apoptotic response

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Fig. 2

Morphological defects in L11-deficient embryos are rescued by rpl11 mRNA.

(A) Morphology of L11-deficient embryos (24 hpf) coinjected separately with rpl11 mRNA and GFP mRNA. rpl11 mRNA (25 ng/µl) coinjected with rpl11 MO (0.5 μg/μl) completely recovers the body length in 24 hpf embryos, but GFP mRNA does not produce any recovery. Insets show the rescue of brain parts such as midbrain-hindbrain boundary (arrow) in the embryos coinjected with rpl11mRNA, but not in GFP mRNA–coinjected embryos. (B) Morphological observation of the rpl11 mRNA and GFP mRNA–coinjected embryos at 3 dpf. The rpl11 mRNA–coinjected embryos have proper head and eye phenotypes, similar to those of the wild-type embryos, whereas GFP mRNA-coinjected embryos display smaller heads and eyes (black curved line) and pericardial edema (arrow). Scale bars: A, inset, 100 μm; B, 500 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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