FIGURE

Fig. 6

ID

ZDB-FIG-081007-13

Publication

Huang et al., 2008 - Mypt1-mediated spatial positioning of Bmp2-producing cells is essential for liver organogenesis

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Fig. 6

The mypt1^sq181 mutation alters actin assembly in LPM and endoderm cells and causes a posterior shift of the liver primordium. (A,B) Cross-sections from wild-type (WT) and mutant (mu) zebrafish embryos in the Tg(gutGFP)^S584 background (green) stained with phalloidin (red). (C-F) High-magnification views of boxed regions in A (C,D) and B (E,F) showing abnormal aggregations of actin filaments (arrows) and cell organization in the mutant endoderm (C versus E) and LPM (D versus F) cells. (G,H) WISH using insulin (for islet, blue arrowheads) and hhex (for liver, arrow) probes, and F59 antibody (for somites, horizontal black lines) on mutants (mu) and wild-type (wt) embryos.

Expression Data

Genes:	GFP hhex ins
Antibody:	Ab-F59
Fish:	AB ppp1r12a^sq181/sq181 (AB) s854Tg ppp1r12a^sq181/sq181; s854Tg (AB)
Anatomical Terms:	gut hepatocyte liver posterior pancreatic bud somite
Stage Range:	Prim-5 to Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ppp1r12a^sq181/sq181 (AB) ppp1r12a^sq181/sq181; s854Tg (AB)
Observed In:	endodermal cell actin filament bundle gut endodermal cell lateral plate mesoderm actin filament bundle lateral plate mesoderm mesodermal cell liver development liver primordium
Stage Range:	Prim-5 to Prim-15

Phenotype Detail

Acknowledgments

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