FIGURE

Fig. 4

ID

ZDB-FIG-080401-4

Publication

Nakayama et al., 2008 - Fgf19 is required for zebrafish lens and retina development

Other Figures

All Figure Page

Back to All Figure Page

Fig. 4

Expression of lens-specific marker genes at 24 hpf. Embryos were injected with control MO (a, c, e, g, j), Fgf19 MO1 (b, d, f, h, k) and Fgf19 mRNA (i, l). (a–d) The expression of βB1-crystallin (a, b) and mafb (c, d) was detected in the lens region of control MO-injected and Fgf19 MO1-injected embryos, while the expression domains in Fgf19 MO1-injected embryos were smaller than those in control embryos. (e, f) On the other hand, the expression of b3gnt5 was not detected in the lens region of Fgf19 MO1-injected embryos. (g, h) The expression of prox1 was detected in the lens region of control MO-injected and Fgf19 MO1-injected embryos. (i) In Fgf19 mRNA-injected embryos, the ectopic expression of prox1 was not detected. (j, k) In Fgf19 MO1-injected embryos, c-maf expression was lost in the lens fiber cells. (l) The ectopic expression of c-maf was not detected in Fgf19 mRNA-injected embryos. Dorsal views with anterior to the top.

Expression Data

Genes:	b3gnt5a crybb1 mafa mafba prox1a
Fish:	WT WT + MO1-fgf19
Knockdown Reagent:	MO1-fgf19
Anatomical Term:	solid lens vesicle
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 313(2), Nakayama, Y., Miyake, A., Nakagawa, Y., Mido, T., Yoshikawa, M., Konishi, M., and Itoh, N., Fgf19 is required for zebrafish lens and retina development, 752-766, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.