ZFIN ID: ZDB-GENE-010813-1
Gene Name: crystallin, beta B1
Gene Symbol: crybb1    Nomenclature History

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Previous Name: zgc:92706

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to be a structural constituent of eye lens. Predicted to be involved in lens development in camera-type eye and visual perception. Human ortholog(s) of this gene implicated in cataract and cataract 17 multiple types. Is expressed in lens and solid lens vesicle. Orthologous to human CRYBB1 (crystallin beta B1).
Genome Resources: Alliance (1),  Gene:114418 (1),  Ensembl(GRCz11):ENSDARG00000068507 (1)
GENE EXPRESSION
All Expression Data: 26 figures from 12 publications
Directly Submitted Expression Data: 7 figures (9 images) from Thisse et al., 2004 [MGC:92706]
  7 figures (8 images) from Thisse et al., 2005 [eu311]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-crybb1
2
PHENOTYPE No data available
DISEASE ASSOCIATED WITH crybb1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cataract 17 multiple types Alliance Cataract 17, multiple types 611544
DISEASE ASSOCIATED WITH crybb1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process visual perception (more)
Molecular Function structural constituent of eye lens (more)
GO Terms (all 3)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR001064 Beta/gamma crystallin
Homologous_superfamily IPR011024 Gamma-crystallin-like
Family IPR033059 Beta-crystallin B1
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA crybb1-201 (1)    Ensembl 933
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM crybb1
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(crybb1:CFP) crybb1 CFP Danio rerio 1 2
Tg(crybb1:ECFP,LEXOP:mCherry) crybb1 ECFPmCherry Danio rerio 1 2
Tg(crybb1:ECFP,LEXOP:mCherry-Hsa.HRAS_G12V) crybb1LEXOP ECFPmCherry Danio rerioHomo sapiens 1 2
Tg(crybb1:ECFP,LEXOP:mCherry-Hsa.KRAS_G12V) crybb1LEXOP ECFPmCherry Danio rerioHomo sapiens 1 2
Tg(crybb1:ECFP,LEXOP:mCherry-Hsa.NRAS_K61Q) crybb1LEXOP ECFPmCherry Danio rerioHomo sapiens 1 2
Tg(crybb1:mCherry,LEXOP:EGFP-kras_G12V) crybb1 EGFPkrasmCherry Danio rerio 1 6
Tg(crybb1:mCherry,LEXOP:EGFP-myca) crybb1LEXOP EGFPmCherrymyca Danio rerio 1 2
Tg(crybb1:mCherry,LEXOP:EGFP-mycb) crybb1LEXOP EGFPmCherrymycb Danio rerio 1 2
Tg(crybb1:mCherry,LEXOP:NLS-Cre) crybb1LEXOP CremCherryNLS Danio rerio 1 1
tg(cyp19a1a:egfp,crybb1:ecfp) crybb1cyp19a1a ECFPEGFP Danio rerio 1 1
Tg(EPV.Tp1:QF,crybb1:ECFP) crybb1 ECFPQF Danio rerio 1 2
Tg(fabp10a:QF,crybb1:ECFP) crybb1fabp10a ECFPQF Danio rerio 1 2
Tg(ins:QF,crybb1:ECFP) crybb1ins ECFPQF Danio rerio 1 2
TgBAC(cdh2:cdh2-EGFP,crybb1:ECFP) cdh2crybb1 cdh2ECFPEGFP Danio rerio 1 8
TgBAC(cdh2:cdh2-sfGFP-TagRFP,crybb1:ECFP) cdh2 cdh2crybb1ECFPGFPTagRFP Danio rerio 1 10
TgBAC(cdh2:cdh2-TagRFP,crybb1:ECFP) cdh2crybb1 cdh2ECFPTagRFP Danio rerio 1 3
TgBAC(cxcr4b:cxcr4b-TagRFP-sfGFP,crybb1:ECFP) crybb1cxcr4b ECFPGFPTagRFP Danio rerio 1 6
TgBAC(cxcr4b:LY-TagRFP-sfGFP,crybb1:ECFP) crybb1cxcr4b ECFPGFPTagRFP Danio rerio 1 4
MARKER RELATIONSHIPS
crybb1 Contained in: [BAC] CH211-122A17 (1)
crybb1 Encodes: [EST] eu311 (1)
[cDNA] MGC:92706 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_173231 (1) 1082 bp
Genomic GenBank:CR384089 (1) 92630 bp
Select Tool
Polypeptide UniProtKB:F1QT01 (1) 253 aa
Sequence Information (all 16)
ORTHOLOGY for crybb1 ( Chr: 10 )
CITATIONS (63)