FIGURE

Fig. 8

ID

ZDB-FIG-080312-7

Publication

Vinothkumar et al., 2008 - Sequential and cooperative action of Fgfs and Shh in the zebrafish retina

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Fig. 8

Shh is required for transgene expression in the retina. (A–C) shh signaling mutants slow muscle omitted (smu) shows complete loss of GFP expression retina (B) while sonic-you can express GFP at the initiation site (arrow) (C) when compared to -2.4shh:gfpABC transgenic line at 72 hpf (A). Embryos treated forskolin from 24 to 48 hpf show only initiation of GFP expression (arrowhead) (E) when compared to control embryos treated with DMSO (D). Forskolin- embryos recover expression in the retina after removal of the chemical as seen at 54 hpf (F). Anterior is top in all images. L, lens. Scale bar, 50 μm.

Expression Data

Gene:	GFP
Fish:	sb15Tg Df(Chr07)t4/t4; sb15Tg smo^b577/b577; sb15Tg
Condition:	chemical treatment: forskolin
Anatomical Term:	retina
Stage Range:	Long-pec to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 314(1), Vinothkumar, S., Rastegar, S., Takamiya, M., Ertzer, R., and Strähle, U., Sequential and cooperative action of Fgfs and Shh in the zebrafish retina, 200-214, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.