Fig. 6
- ID
- ZDB-FIG-080312-5
- Publication
- Vinothkumar et al., 2008 - Sequential and cooperative action of Fgfs and Shh in the zebrafish retina
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FGF signaling is required for initiation and propagation of GFP expression. (A) Scheme of SU5402 treatment at different time points. (B, E) Treatment of embryos with DMSO at any time does not show alterations in transgene expression. Embryos treated with SU5402 from 24 hpf show a complete loss of expression in the retina (C) while those treated from 34 hpf show a few GFP cells (arrow) at the initiation point (F). Expression recovered when the embryos were removed from SU5402 at 48 hpf and allowed to grow until 72 hpf (D, G). Confocal pictures at 48 hpf (B, C, E, F) and 72 hpf (D, G) with anterior to the top. L, lens. Scale bar, 50 μm. |
Reprinted from Developmental Biology, 314(1), Vinothkumar, S., Rastegar, S., Takamiya, M., Ertzer, R., and Strähle, U., Sequential and cooperative action of Fgfs and Shh in the zebrafish retina, 200-214, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.