FIGURE

Fig. 7

ID

ZDB-FIG-080114-36

Publication

Yeh et al., 2008 - AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression

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Fig. 7

AML1-ETO suppresses the monocytic cell fate. (A) In situ hybridization of l-plastin, mpo and pu.1. Tg(hsp:AML1-ETO) embryos were injected with gata1 morpholino (MO). Half of the injected embryos were heat-treated to induce AML1-ETO expression. AML1-ETO suppresses the expression of pu.1 and l-plastin but promotes the expression of mpo in gata1 morphants. (B) In situ hybridization of mpo. Injections of pu.1 MO decreased the expression of mpo in AML1-ETO-expressing embryos, inicating that Pu.1 is essential for the specification of granulocytes.

Expression Data

Genes:	lcp1 mpx spi1b
Fish:	f3Tg f3Tg + MO1-gata1a f3Tg + MO4-spi1b
Condition:	heat shock
Knockdown Reagents:	MO1-gata1a MO4-spi1b
Anatomical Terms:	granulocyte granulocyte monocyte progenitor cell monocyte
Stage Range:	26+ somites to Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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