FIGURE

Fig. 9

ID

ZDB-FIG-080114-38

Publication

Yeh et al., 2008 - AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression

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Fig. 9

Trichostatin A suppresses the effects of AML1-ETO in zebrafish embryos. (A-C) DMSO or 0.5 µM TSA was added to Tg(hsp:AML1-ETO) embryos 2 hours before (A,B) or at the end of a 1-hour heat treatment (C) at 38°C at 18 hpf. Tg(hsp:AML1-ETO) embryos that had not been subjected to the heat treatment were used as a control. TSA treatment rescues scl and gata1 downregulation and blocks the accumulation of Mpo⁺ cells caused by AML1-ETO expression.

Expression Data

Genes:	gata1a mpx tal1
Fish:	f3Tg
Conditions:	heat shock chemical treatment: trichostatin A, heat shock
Anatomical Terms:	granulocyte head hematopoietic multipotent progenitor cell megakaryocyte erythroid progenitor cell tail bud vascular endothelium
Stage Range:	20-25 somites to Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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