FIGURE

Fig. 7

ID

ZDB-FIG-070801-16

Publication

Jin et al., 2007 - A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos

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Fig. 7

Mutations affecting vascular maintenance and integrity. (A–R) Bright-field (A, D, G, J, M, and P) and epifluorescent (B, C, E, F, H, I, K, L, N, O, Q, and R) micrographs of Tg(flk1:EGFP)^s843adr^s277 mutant larvae (D–F) and wild-type siblings (A–C), wdi^s631 mutant larvae (J–L) and wild-type siblings (G–I), and bar^s847 mutant larvae (P–R) and wild-type siblings (M–O) at 72 hpf. Affected areas within epifluorescent micrographs are magnified and shown in panels C, F, I, L, O, and R. Note the massive vascular dilation throughout the head vasculature in adr^s277 mutant larvae (F arrowheads), regression of the dorsal aorta in wdi^s631 mutant larvae (asterisk in panels L; K, L), and apparently disappearing endothelial cells in bar^s847 mutant larvae (Q, R).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sars1^s277/s277; s843Tg ubiad1^s847/s847; s843Tg wdi^s631/s631; s843Tg
Observed In:	blood vessel endothelial cell blood vessel morphogenesis cranial vasculature dorsal aorta
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 307(1), Jin, S.W., Herzog, W., Santoro, M.M., Mitchell, T.S., Frantsve, J., Jungblut, B., Beis, D., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Field, H.A., Chi, N.C., Wehman, A.M., Baier, H., and Stainier, D.Y., A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos, 29-42, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.