ZFIN Image: Jin et al., 2007, Fig. 7

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Figure Caption

Fig. 7 Mutations affecting vascular maintenance and integrity. (A–R) Bright-field (A, D, G, J, M, and P) and epifluorescent (B, C, E, F, H, I, K, L, N, O, Q, and R) micrographs of Tg(flk1:EGFP)^s843adr^s277 mutant larvae (D–F) and wild-type siblings (A–C), wdi^s631 mutant larvae (J–L) and wild-type siblings (G–I), and bar^s847 mutant larvae (P–R) and wild-type siblings (M–O) at 72 hpf. Affected areas within epifluorescent micrographs are magnified and shown in panels C, F, I, L, O, and R. Note the massive vascular dilation throughout the head vasculature in adr^s277 mutant larvae (F arrowheads), regression of the dorsal aorta in wdi^s631 mutant larvae (asterisk in panels L; K, L), and apparently disappearing endothelial cells in bar^s847 mutant larvae (Q, R).

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Acknowledgments

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Reprinted from Developmental Biology, 307(1), Jin, S.W., Herzog, W., Santoro, M.M., Mitchell, T.S., Frantsve, J., Jungblut, B., Beis, D., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Field, H.A., Chi, N.C., Wehman, A.M., Baier, H., and Stainier, D.Y., A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos, 29-42, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.