FIGURE

Fig. 1

ID

ZDB-FIG-070801-10

Publication

Jin et al., 2007 - A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos

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Fig. 1

Mutations affecting specification of endothelial precursors. (A–D) Epifluorescent micrographs of 36 hpf wild-type (A), clo^s5 mutant (B), min^s202 mutant (C), and grc^s635 mutant (D) embryos visualized by Tg(flk1:EGFP)^s843 expression. Morphologically, grc^s635 and min^s202 mutant embryos show no obvious defects, but the number of endothelial cells appears significantly reduced (C and D), a reduction comparable to that seen in clo^s5 mutant embryos (B). White arrows point to region with Tg(flk1:EGFP)^s843 positive endothelial cells are conspicuously missing.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	etsrp^s635/s635; s843Tg min^s202/s202; s843Tg npas4l^s5/s5; s843Tg
Observed In:	blood vessel endothelial cell
Stage:	Prim-25

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 307(1), Jin, S.W., Herzog, W., Santoro, M.M., Mitchell, T.S., Frantsve, J., Jungblut, B., Beis, D., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Field, H.A., Chi, N.C., Wehman, A.M., Baier, H., and Stainier, D.Y., A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos, 29-42, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.