FIGURE

Fig. 5

ID

ZDB-FIG-070613-69

Publication

Shin et al., 2007 - Bmp and Fgf signaling are essential for liver specification in zebrafish

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Fig. 5

Gata4 and Gata6 are required for the expansion and differentiation of liver progenitors. Wild-type zebrafish embryos were injected with 10 ng gata4 MO and/or 2.5 ng gata6 MO, harvested at 37-38 hpf and examined for hhex (A-E), prox1 (F-J) and cp (K-N) expression. Injections of gata4 or gata6 MO weakly reduced hhex and prox1 expression in the liver region (B,C,G,H); injections of both MOs together strongly reduced their expression (D,E,I,J), but did not completely abolish it. Injections of gata4, gata6 or both MOs severely affected hepatocyte differentiation, as shown by cp expression (L-N). All images are dorsal views, anterior left (n=13-20).

Expression Data

Genes:	cp hhex prox1a
Fish:	WT WT + MO1-gata4 WT + MO1-gata6 WT + MO1-gata4 + MO1-gata6
Knockdown Reagents:	MO1-gata4 MO1-gata6
Anatomical Terms:	hepatocyte interrenal primordium liver pancreatic bud
Stage:	Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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