FIGURE

Fig. 5

ID

ZDB-FIG-070126-5

Publication

Lee et al., 2006 - Blimp-1 is an essential component of the genetic program controlling development of the pectoral limb bud

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Fig. 5

blimp-1 acts downstream of tbx5 and fgf24. (A-F) tbx5 expression in the fin buds (arrows) of wild-type and blimp-1 morphants. (G and H) fgf24 expression (arrows) in a wild-type embryo and a blimp-1 morphant. (I) A wild-type fin, showing fgf24 expression in the AER (arrow). (J) A blimp-1 morphant at the same stage, showing absence of fgf24 from the ectoderm (black arrow) and its continued expression in the mesenchyme (white arrow). (K and L) blimp-1 expression is absent (arrows) from the prospective fin buds of tbx5 and fgf24 MO injected embryos. All panels depict dorsal views, except panels I and J, which depict lateral views.

Expression Data

Genes:	fgf24 prdm1a tbx5a
Fish:	WT WT + MO1-tbx5a WT + MO2-fgf24 WT + MO2-prdm1a
Knockdown Reagents:	MO1-tbx5a MO2-fgf24 MO2-prdm1a
Anatomical Terms:	fin fold pectoral fin bud mesenchyme pectoral fin pectoral fin bud
Stage Range:	Prim-5 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 300(2), Lee, B.C., and Roy, S., Blimp-1 is an essential component of the genetic program controlling development of the pectoral limb bud, 623-634, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.