FIGURE

Fig. 3

ID

ZDB-FIG-061121-18

Publication

Eroglu et al., 2006 - Critical role of Brg1 member of the SWI/SNF chromatin remodeling complex during neurogenesis and neural crest induction in zebrafish

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Fig. 3

Reduction in Brg1 expression leads to aberrant expression of genes involved in neurodevelopment. In situ hybridization analyses showing the expression of various markers in control-MO-injected (10 ng/embryo) or Brg1-MO-injected (10 ng/embryo) embryos at indicated time points. The markers were as follows: six3 (A,B), eng2 (C-F), krox-20 (G-J), myoD (K,L), gsc (M,N), ntl (O-R), and hlx1 (S,T). Morphant phenotypes were more than 90%, n = 40. Embryos are dorsal view (A-P) or lateral view (Q-T). For in situ hybridization analyses, a total of 3,000 embryos was injected and 200 embryos were used per probe. No nonspecific hybridization was observed with sense probes (data not shown). Embryos were photographed using a SPOT camera mounted on a dissecting microscope. Morphant phenotypes were more than 90%, n = 30. Original magnification 40×.

Expression Data

Genes:	egr2b en2a gsc hlx1 myod1 six3a tbxta
Fish:	WT + MO1-smarca4a
Knockdown Reagent:	MO1-smarca4a
Anatomical Terms:	brain neural keel neural plate neuroectoderm notochord presumptive rhombomere 3 presumptive rhombomere 5 somite unspecified
Stage Range:	1-4 somites to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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