ZFIN ID: ZDB-GENE-980528-2060
Gene Name: goosecoid
Gene Symbol: gsc    Nomenclature History

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Previous Names: etID102410.17 (1), etID5964.17 (1), ik:tdsubc_1c10 (1), ik:tdsubc_2g4 (1), ik:tdsubc_2h11, xx:tdsubc_1c10, xx:tdsubc_2g4, xx:tdsubc_2h11, zgc:101595, ZGSC

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have sequence-specific DNA binding activity. Involved in several processes, including neuroblast delamination; otic vesicle development; and regionalization. Predicted to localize to the nucleus. Is expressed in several structures, including blastodisc; germ ring; mesoderm; neural keel; and pharyngeal arch. Orthologous to human GSC (goosecoid homeobox).
Genome Resources: Alliance (1),  Gene:30212 (1),  Ensembl(GRCz11):ENSDARG00000059073 (1)
GENE EXPRESSION
All Expression Data: 366 figures from 272 publications
Directly Submitted Expression Data: 8 figures (68 images) from Thisse et al., 2004 [MGC:101595]
  1 figure (1 image) from Thisse et al., 2005 [eu565]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa32143 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • x59 Indel Unknown Unknown TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-gsc N/A 3
    MO2-gsc N/A 1
    MO3-gsc N/A 1
    TALEN1-gsc 1
    DISEASE ASSOCIATED WITH gsc HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Short stature, auditory canal atresia, mandibular hypoplasia, skeletal abnormalities 602471
    DISEASE ASSOCIATED WITH gsc VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anterior/posterior axis specification (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR017970 Homeobox, conserved site
    Domain IPR001356 Homeobox domain
    Homologous_superfamily IPR009057 Homeobox-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gsc-201 (1)    Ensembl 1276
    gsc-202 (1)    Ensembl 1153
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM gsc
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-1.8gsc:GFP) gsc GFP Danio rerio 1 31
    Tg(-3gsc:GFP) gsc GFP Danio rerio 1 2
    Tg(-4gsc:EGFP) gsc EGFP Danio rerio 1 4
    Tg(-4gsc:EGFP-Hsa.HRAS) gsc EGFP Danio rerioHomo sapiens 1 3
    Tg(-6gsc:EGFP-CAAX) gsc CAAXEGFP Danio rerio 1 4
    Tg(gsc:Cre) gsc Cre Danio rerio 1 1
    Tg(gsc:GAL4-VP16) gsc GAL4VP16 Danio rerio 1 3
    Tg(gsc:GFP) gsc GFP Danio rerio 1 1
    Tg(gsc:TurboRFP) gsc RFP Danio rerio 1 3
    Tg(hsp70l:gsc) hsp70l gsc Danio rerio 1 1
    MARKER RELATIONSHIPS
    gsc Contained in: [BAC] DKEY-49F1 (1) (order this)
    gsc Encodes: [EST] eu565 (1), tdsubc_1c10 (1), tdsubc_2g4 (1), tdsubc_2h11 (1)
    [cDNA] MGC:101595 (1), MGC:192260 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131017 (1) 1252 nt
    Genomic GenBank:AL772209 (1) 202805 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B2GRD3 (1) 240 aa
    Sequence Information (all 29)
    ORTHOLOGY for gsc ( Chr: 17 )
    CITATIONS (515)