Gene
en2a
- ID
- ZDB-GENE-980526-167
- Name
- engrailed homeobox 2a
- Symbol
- en2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within apoptotic process involved in morphogenesis; cell fate specification; and nervous system development. Predicted to be active in nucleus. Is expressed in several structures, including adaxial cell; central nervous system; muscle; neural plate; and pharyngeal arch. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EN2 (engrailed homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 106 figures from 75 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu759 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Scholpp et al., 2001
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR000047 | Helix-turn-helix motif |
| Conserved_site | IPR017970 | Homeobox, conserved site |
| Conserved_site | IPR019737 | Homeobox engrailed-type, conserved site |
| Domain | IPR000747 | Homeodomain engrailed |
| Domain | IPR001356 | Homeodomain |
| Domain | IPR019549 | Homeobox engrailed, C-terminal |
| Domain | IPR020479 | Homeodomain, metazoa |
| Family | IPR050720 | Engrailed Homeobox Transcription Factors |
| Homologous_superfamily | IPR009057 | Homedomain-like superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Engrailed Homeobox Transcription Factors | Helix-turn-helix motif | Homedomain-like superfamily | Homeobox, conserved site | Homeobox engrailed, C-terminal | Homeobox engrailed-type, conserved site | Homeodomain | Homeodomain engrailed | Homeodomain, metazoa |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:P09015 | InterPro | 265 | |||||||||
| UniProtKB:B3DGA1 | InterPro | 265 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids