Gene

en2a

ID

ZDB-GENE-980526-167

Name

engrailed homeobox 2a

Symbol

en2a Nomenclature History

Previous Names

eng2 (1)
eng2a
Zf-en (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within apoptotic process involved in morphogenesis; cell fate specification; and nervous system development. Predicted to be active in nucleus. Is expressed in several structures, including adaxial cell; central nervous system; muscle; neural plate; and pharyngeal arch. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EN2 (engrailed homeobox 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

103 figures from 73 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu759 (15 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Scholpp et al., 2001
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With en2a Human Ortholog

No data available

Associated With en2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000047	Helix-turn-helix motif
Conserved_site	IPR017970	Homeobox, conserved site
Conserved_site	IPR019737	Homeobox engrailed-type, conserved site
Domain	IPR000747	Homeobox domain engrailed
Domain	IPR001356	Homeobox domain
Domain	IPR019549	Homeobox engrailed, C-terminal
Domain	IPR020479	Homeobox domain, metazoa
Homologous_superfamily	IPR009057	Homeobox-like domain superfamily