ZFIN ID: ZDB-GENE-980526-167
Gene Name: engrailed homeobox 2a
Gene Symbol: en2a    Nomenclature History

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Previous Names: eng2 (1), eng2a, Zf-en (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have sequence-specific DNA binding activity. Involved in apoptotic process involved in morphogenesis; cell fate specification; and nervous system development. Predicted to localize to RSC-type complex. Is expressed in several structures, including adaxial cell; central nervous system; muscle; neural plate; and pharyngeal arch. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EN2 (engrailed homeobox 2).
Genome Resources: Alliance (1),  Gene:30243 (1),  Ensembl(GRCz11):ENSDARG00000026599 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-en2a N/A 5
MO2-en2a N/A 1
MO3-en2a N/A 1
PHENOTYPE
Data: Fig. 1 from Scholpp et al., 2001
Observed in:
DISEASE ASSOCIATED WITH en2a HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH en2a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process anterior/posterior pattern specification (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 15)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA en2a-201 (1)    Ensembl 2910
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-eng monoclonal IgG1 , k Mouse IHC Developmental Studies Hybridoma Bank
113
Ab2-eng polyclonal Rabbit IHC 4
CONSTRUCTS WITH SEQUENCES FROM en2a
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(-8en2a:EGFP) en2a EGFP Danio rerio 1 2
Tg(-10en2a:EGFP) en2a EGFP Danio rerio 1 9
Tg1(en2a:EGFP) en2a EGFP Danio rerio 2 3
Tg2(en2a:EGFP) en2a EGFP Danio rerio 1 2
Tg3(en2a:EGFP) en2a EGFP Danio rerio 1 2
Tg4(en2a:EGFP) en2a EGFP Danio rerio 1 2
Tg5(en2a:EGFP) en2a EGFP Danio rerio 1 2
Tg6(en2a:EGFP) en2a EGFP Danio rerio 1 2
Tg7(en2a:EGFP) en2a EGFP Danio rerio 1 2
Tg8(en2a:EGFP) en2a EGFP Danio rerio 1 3
Tg9(en2a:EGFP) en2a EGFP Danio rerio 1 2
Tg10(en2a:EGFP) en2a EGFP Danio rerio 1 2
Tg11(en2a:EGFP) en2a EGFP Danio rerio 1 2
Tg12(en2a:EGFP) en2a EGFP Danio rerio 1 3
Tg13(en2a:EGFP) en2a EGFP Danio rerio 1 3
Tg14(en2a:EGFP) en2a EGFP Danio rerio 1 3
Tg15(en2a:EGFP) en2a EGFP Danio rerio 1 3
Tg16(en2a:EGFP) en2a EGFP Danio rerio 1 2
MARKER RELATIONSHIPS
en2a Contained in: [BAC] CH211-105D1 (1), CH211-150E22 (1)
en2a Encodes: [EST] eu759 (1)
[cDNA] MGC:193941 (1), MGC:193943 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131044 (1) 2607 nt
Genomic GenBank:CU041319 (1) 174262 nt
Select Tool
Polypeptide UniProtKB:B3DGA1 (1) 265 aa
Sequence Information (all 25)
ORTHOLOGY for en2a ( Chr: 7 )
CITATIONS (161)