ZFIN Gene: six3a

ZFIN ID: ZDB-GENE-990415-127

ZFIN ID: ZDB-GENE-990415-127

Gene Name:

SIX homeobox 3a

Gene Symbol:

six3a

Sequence Ontology ID :

SO:0001217

Previous Names:

six3.1, six3 (1), etID309945.13 (1), etID46760.13 (1), wu:fa01b08, wu:fc10a08 (1)

Location:

Chr: 13 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and transcription regulatory region sequence-specific DNA binding activity. Involved in brain development and ...

GENE EXPRESSION
All Expression Data:	41 figures from 37 publications
Wild-type Stages, Structures:	Gastrula:Shield (6.0h-8.0h) to Adult (90d-730d, breeding adult)
	anterior neural keel anterior neural plate anterior neural rod anterior neural tube anterior presumptive neural plate eye forebrain forebrain neural keel forebrain neural plate head medial longitudinal fasciculus midbrain hindbrain boundary neural keel neural plate optic vesicle preoptic area dopaminergic neuron presumptive telencephalon retina retinal ganglion cell layer retinal inner nuclear layer rhombomere 2 unspecified whole organism
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa42147	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
vu129	Point Mutation	Unknown	Unknown	ENU

Targeting reagents:

PHENOTYPE No data available

DISEASE ASSOCIATED WITH six3a HUMAN ORTHOLOG

Disease Ontology Term	OMIM Term	OMIM Phenotype ID
holoprosencephaly 2	Holoprosencephaly 2	157170
	Schizencephaly	269160

DISEASE ASSOCIATED WITH six3a VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	optic nerve development (more)
Cellular Component	nucleus (more)
Molecular Function	DNA binding (more)

GO Terms (all 12)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR001356 (1) InterPro:IPR009057 (1) InterPro:IPR031701 (1) InterPro:IPR032949 (1)	PROSITE:PS50071 (1)	Pfam:PF00046 (1) Pfam:PF16878 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	six3a-201 (1)	1889	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM six3a

Tg(-3.6six3a:EGFP)

MARKER RELATIONSHIPS

six3a Contained in:	[BAC] DKEY-103L3 (1) (order this)
six3a Encodes:	[EST] fc10a08 (1) [cDNA] MGC:73025 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_131362 (1)	1914 bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX537274 (1)	151298 bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:O73708 (1)	294 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:616 (1)

Sequence Information (all 15)

OTHER six3a GENE PAGES

Alliance (1)

Gene:30635 (1)

VEGA:OTTDARG00000020674 (1)

Ensembl(GRCz11):ENSDARG00000058008 (1)

ORTHOLOGY for six3a ( Chr: 13 )

CITATIONS (91)

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