FIGURE

Fig. 7

ID

ZDB-FIG-051220-34

Publication

Miyake et al., 2005 - Fgf19 regulated by Hh signaling is required for zebrafish forebrain development

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Fig. 7

Interactions between Fgf19, Fgf3 and Fgf8 in the forebrain and midbrain. (A–D) Embryos were injected with control Fgf19 MO (A and C), Fgf19 MO (B and D) at 25 hpf. In the Fgf19 MO-injected embryos, Fgf3 (A and B) and Fgf8 (C and D) were expressed normally in the MHB (arrows) but the expression of Fgf3 and Fgf8 was up-regulated in the forebrain (arrowheads). (E and F) Fgf19 expression in embryos injected with standard control MO (E), and Fgf3 MO and Fgf8 MO (F) at 25 hpf. (E) In the embryos injected with standard control MO, Fgf19 was normally expressed. (F) In the embryos injected with both Fgf3 MO and Fgf8 MO, Fgf19 expression in the forebrain was unaffected, while that in the midbrain (arrow) decreased. Lateral views with anterior to the left and dorsal to the top.

Expression Data

Genes:	fgf3 fgf8a fgf19
Fish:	WT + MO1-fgf19 WT + MO1-fgf3 + MO3-fgf8a
Knockdown Reagents:	MO1-fgf3 MO1-fgf19 MO3-fgf8a
Anatomical Terms:	forebrain midbrain midbrain hindbrain boundary
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 288(1), Miyake, A., Nakayama, Y., Konishi, M., and Itoh, N., Fgf19 regulated by Hh signaling is required for zebrafish forebrain development, 259-275, Copyright (2005) with permission from Elsevier. Full text @ Dev. Biol.