Gene
fgf19
- ID
- ZDB-GENE-030729-32
- Name
- fibroblast growth factor 19
- Symbol
- fgf19 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Acts upstream of or within several processes, including camera-type eye development; nervous system development; and positive regulation of neurogenesis. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including digestive system; nervous system; optic vesicle; presumptive neural retina; and solid lens vesicle. Orthologous to human FGF19 (fibroblast growth factor 19).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu879 (6 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-fgf19 | N/A | (5) |
| MO2-fgf19 | N/A | Nakayama et al., 2008 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytokine IL1/FGF | Fibroblast growth factor 15/19/21 | Fibroblast growth factor family |
|---|---|---|---|---|---|
| UniProtKB:A0A8M1N428 | InterPro | 141 | |||
| UniProtKB:A0A0R4IN60 | InterPro | 209 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-188I17 | ||
| Encodes | EST | eu879 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:194276 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001012246 (1) | 920 nt | ||
| Genomic | GenBank:AL929586 (1) | 154808 nt | ||
| Polypeptide | UniProtKB:A0A0R4IN60 (1) | 209 aa |
- Cudak, N., López-Delgado, A.C., Keil, S., Knopf, F. (2023) Fibroblast growth factor pathway component expression in the regenerating zebrafish fin. Gene expression patterns : GEP. 48:119307
- Blitz, E., Matsuda, H., Guenther, S., Morikawa, T., Kubota, Y., Zada, D., Lerer-Goldshtein, T., Stainier, D.Y.R., Appelbaum, L. (2021) Thyroid hormones regulate goblet cell differentiation and Fgf19-Fgfr4 signaling. Endocrinology. 162(5):
- Wen, J., Mercado, G.P., Volland, A., Doden, H.L., Lickwar, C.R., Crooks, T., Kakiyama, G., Kelly, C., Cocchiaro, J.L., Ridlon, J.M., Rawls, J.F. (2021) Fxr signaling and microbial metabolism of bile salts in the zebrafish intestine. Science advances. 7(30)
- Maselli, K.M., Gee, K., Isani, M., Fode, A., Schall, K.A., Grikscheit, T.C. (2020) Broad spectrum antibiotics alter the microbiome, increase intestinal fxr, and decrease hepatic steatosis in zebrafish short bowel syndrome. American journal of physiology. Gastrointestinal and liver physiology. 319(2):G212-G226
- Gallegos, T.F., Kamei, C.N., Rohly, M., Drummond, I.A. (2019) Fibroblast growth factor signaling mediates progenitor cell aggregation and nephron regeneration in the adult zebrafish kidney. Developmental Biology. 454(1):44-51
- Umali, J., Hawkey-Noble, A., French, C.R. (2019) Loss of foxc1 in zebrafish reduces optic nerve size and cell number in the ganglion cell layer. Vision Research. 156:66-72
- Xiong, G., Deng, Y., Li, J., Cao, Z., Liao, X., Liu, Y., Lu, H. (2019) Immunotoxicity and transcriptome analysis of zebrafish embryos in response to glufosinate-ammonium exposure. Chemosphere. 236:124423
- He, H., Wang, C., Tang, Q., Yang, F., Xu, Y. (2018) Elucidation of possible molecular mechanisms underlying the estrogen-induced disruption of cartilage development in zebrafish larvae. Toxicology letters. 289:22-27
- Lacave, J.M., Vicario-Parés, U., Bilbao, E., Gilliland, D., Mura, F., Dini, L., Cajaraville, M.P., Orbea, A. (2018) Waterborne exposure of adult zebrafish to silver nanoparticles and to ionic silver results in differential silver accumulation and effects at cellular and molecular levels. The Science of the total environment. 642:1209-1220
- Shibata, E., Yokota, Y., Horita, N., Kudo, A., Abe, G., Kawakami, K., Kawakami, A. (2016) Fgf signalling controls diverse aspects of fin regeneration. Development (Cambridge, England). 143:2920-9
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