FIGURE

Fig. 2

ID

ZDB-FIG-050208-2

Publication

Dooley et al., 2005 - Zebrafish scl functions independently in hematopoietic and endothelial development

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Fig. 2

Loss of embryonic erythroid development inscl morphants. (A, B) Loss of gata1 expression as detected by ISH in the scl morphants at the 10-somite stage. (C) Co-injection of 300 pg of scl RNA rescued the gata1 expression. Loss of transcripts for runx1 (D, E) and c-myb (F, G) at the 10 somite stage, and βe3-globin transcripts at 24 hpf (H, I), in scl morphants. (J, K) Absence of circulating erythroid cells in the scl morphant embryos (arrow), in comparison to uninjected control embryos, as visualized under a dissecting microscope. Whole (A–C, H–I) or flat-mounted (D–G) embryos are shown with anterior to the left.

Expression Data

Genes:	gata1a hbbe3 myb runx1
Fish:	WT WT + MO1-tal1 + MO2-tal1
Knockdown Reagents:	MO1-tal1 MO2-tal1
Anatomical Terms:	lateral mesoderm unspecified
Stage Range:	10-13 somites to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 277(2), Dooley, K.A., Davidson, A.J., and Zon, L.I., Zebrafish scl functions independently in hematopoietic and endothelial development, 522-536, Copyright (2005) with permission from Elsevier. Full text @ Dev. Biol.