Gene

hbbe3

ID

ZDB-GENE-980526-287

Name

hemoglobin beta embryonic-3

Symbol

hbbe3 Nomenclature History

Previous Names

[b]_e3globin
beta e3 globin (1)
zgc:110736

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to contribute to haptoglobin binding activity and peroxidase activity. Predicted to be involved in hydrogen peroxide catabolic process. Predicted to localize to haptoglobin-hemoglobin complex and hemoglobin complex. Human ortholog(s) of this gene implicated in sickle cell anemia. Is expressed in erythroid lineage cell; hematopoietic system; mesoderm; presumptive blood; and vasculature. Orthologous to human HBE1 (hemoglobin subunit epsilon 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

81 figures from 56 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hbbe3 Human Ortholog

No data available

Associated With hbbe3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000971	Globin
Family	IPR002337	Hemoglobin, beta-type
Family	IPR050056	Hemoglobin and related oxygen transporters
Homologous_superfamily	IPR009050	Globin-like superfamily
Homologous_superfamily	IPR012292	Globin/Protoglobin