Gene
cyp26a1
- ID
- ZDB-GENE-990415-44
- Name
- cytochrome P450, family 26, subfamily A, polypeptide 1
- Symbol
- cyp26a1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Exhibits retinoic acid 4-hydroxylase activity. Involved in several processes, including animal organ development; cellular response to vitamin A; and retinoid metabolic process. Predicted to localize to endoplasmic reticulum; endoplasmic reticulum membrane; and integral component of membrane. Used to study holoprosencephaly. Is expressed in several structures, including head; mesoderm; neural plate; pleuroperitoneal region; and presumptive neural plate. Orthologous to human CYP26A1 (cytochrome P450 family 26 subfamily A member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 95 figures from 62 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb24 (61 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| holoprosencephaly | cyp26a1rw716/rw716 | standard conditions | Gongal et al., 2008 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450 superfamily |
|---|---|---|---|---|---|
|
UniProtKB:Q7SXV4
|
492 | ||||
|
UniProtKB:P79739
|
492 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp26a1-201
(1)
|
Ensembl | 1,830 nt | ||
| mRNA |
cyp26a1-202
(1)
|
Ensembl | 835 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-cyp26a1 | polyclonal | IgG | Rabbit |
|
AnaSpec
|
2 |
Plasmids
No data available