ZFIN Fish: cyp26a1^rw716/rw716

ZFIN ID: ZDB-FISH-150901-11180

ZFIN ID: ZDB-FISH-150901-11180

Fish name:	cyp26a1^rw716/rw716
Genotype:	cyp26a1^rw716/rw716
Targeting Reagent:	none

HUMAN DISEASE MODELED by cyp26a1^rw716/rw716

Human Disease	Conditions	Citations
holoprosencephaly	standard conditions	Gongal et al., 2008

GENE EXPRESSION
Gene expression in cyp26a1^rw716/rw716

RNA expression

Expressed Gene	Structure	Conditions	Figures
aldh1a2	margin	standard conditions	Fig. 5 from Drummond et al., 2013
arxa	forebrain neural plate	standard conditions	Fig. 5 from Gongal et al., 2008
barhl2	forebrain neural plate	standard conditions	Fig. 5 from Gongal et al., 2008
cyp26b1	presumptive rhombomere 3 presumptive rhombomere 4	control	Fig. 5 from Hernandez et al., 2007
	(not) neural rod	chemical treatment: all-trans-retinoic acid	Fig. 5 from Hernandez et al., 2007
cyp26c1	presumptive rhombomere 2 presumptive rhombomere 3 presumptive rhombomere 4 presumptive rhombomere 5 presumptive rhombomere 6	control	Fig. 5 from Hernandez et al., 2007
	(not) neural rod	chemical treatment: all-trans-retinoic acid	Fig. 5 from Hernandez et al., 2007
dhrs3a	lateral plate mesoderm mesoderm	standard conditions	Fig. 5 from Feng et al., 2010
dlx2a	(not) brain	chemical treatment: 4-(diethylamino)benzaldehyde, chemical treatment: all-trans-retinoic acid	Fig. 4 from Hernandez et al., 2007
egr2b	hindbrain neural rod presumptive rhombomere 3 presumptive rhombomere 5 rhombomere 3 rhombomere 5	control	Fig. S1 from Rydeen et al., 2014 Fig. 8 from Feng et al., 2010 Fig. 4 , Fig. 5 from Hernandez et al., 2007
	(not) brain (not) neural rod presumptive rhombomere 3 presumptive rhombomere 5 rhombomere 3 rhombomere 5	chemical treatment: 4-(diethylamino)benzaldehyde	Fig. 4 , Fig. 5 , Fig. 6 , Fig. S2 from Hernandez et al., 2007
en2a	hindbrain neural rod	standard conditions	Fig. S1 from Rydeen et al., 2014
en2b	(not) brain	chemical treatment: 4-(diethylamino)benzaldehyde, chemical treatment: all-trans-retinoic acid	Fig. 4 from Hernandez et al., 2007
hnf1ba	presumptive rhombomere 6 presumptive rhombomere 7 presumptive rhombomere 8	chemical treatment: all-trans-retinoic acid	Fig. S2 from Hernandez et al., 2007
hoxb1a	(not) brain	chemical treatment: 4-(diethylamino)benzaldehyde, chemical treatment: all-trans-retinoic acid	Fig. 4 from Hernandez et al., 2007
hoxb4a	hindbrain neural rod	standard conditions	Fig. S1 from Rydeen et al., 2014
hoxd4a	hindbrain neural plate rhombomere 7 rhombomere 8	control	Fig. 8 from Feng et al., 2010 Fig. 4 from Hernandez et al., 2007
	hindbrain (not) rhombomere	chemical treatment: 4-(diethylamino)benzaldehyde	Fig. 4 , Fig. 6 from Hernandez et al., 2007
ins	posterior pancreatic bud	control	Fig. 3 from Kinkel et al., 2009
myod1	somite	chemical treatment: 4-(diethylamino)benzaldehyde, chemical treatment: all-trans-retinoic acid	Fig. 4 from Hernandez et al., 2007
nkx2.1	diencephalon	standard conditions	Fig. 5 from Gongal et al., 2008
nkx2.4b	diencephalon	standard conditions	Fig. 5 from Gongal et al., 2008
otx2b	(not) brain	chemical treatment: 4-(diethylamino)benzaldehyde, chemical treatment: all-trans-retinoic acid	Fig. 4 from Hernandez et al., 2007
pax2a	midbrain midbrain hindbrain boundary midbrain hindbrain boundary neural plate optic stalk otic placode otic vesicle rhombic lip somite	control	Fig. 8 from Feng et al., 2010 Fig. 4 from Hernandez et al., 2007
	(not) brain midbrain midbrain hindbrain boundary midbrain hindbrain boundary neural keel optic stalk otic vesicle rhombic lip	chemical treatment: 4-(diethylamino)benzaldehyde	Fig. 4 , Fig. 6 , Fig. S2 from Hernandez et al., 2007
ripply3	whole organism	standard conditions	Fig 7 from Song et al., 2019

Protein expression No data available

Reporter gene expression No data available

PHENOTYPE
Phenotype in cyp26a1^rw716/rw716

Phenotype	Conditions	Figures
heart edematous, abnormal	standard conditions	Fig. S2 from Rydeen et al., 2014
hindbrain edematous, abnormal	standard conditions	Fig. S2 from Rydeen et al., 2014
pancreas increased length, abnormal	control	Fig. 3 from Kinkel et al., 2009
pancreas mislocalised anteriorly, abnormal	control	Fig. 3 from Kinkel et al., 2009
pancreas development process quality, abnormal	control	Fig. 3 from Kinkel et al., 2009
pectoral fin morphology, abnormal	standard conditions	Fig. S6 from He et al., 2011
pectoral fin development disrupted, abnormal	standard conditions	Fig. S6 from He et al., 2011
whole organism ripply3 expression increased amount, abnormal	standard conditions	Fig 7 from Song et al., 2019
whole organism morphology, normal	standard conditions	Fig. S3 from Gongal et al., 2008

CITATIONS (12)