ZFIN ID: ZDB-GENE-990415-44
Gene Name: cytochrome P450, family 26, subfamily A, polypeptide 1
Gene Symbol: cyp26a1    Nomenclature History

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Previous Names: cb24 (1), etID42255.12 (1), gir, giraffe, id:ibd5061 (1), P450RAI, wu:fb81e05 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Exhibits retinoic acid 4-hydroxylase activity. Involved in several processes, including animal organ development; cellular response to vitamin A; and retinoid metabolic process. Predicted to localize to the endoplasmic reticulum; endoplasmic reticulum membrane; and integral component of membrane. Used to study holoprosencephaly. Is expressed in several structures, including head; mesoderm; neural plate; pleuroperitoneal region; and presumptive neural plate. Orthologous to human CYP26A1 (cytochrome P450 family 26 subfamily A member 1).
Genome Resources: Alliance (1),  Gene:30381 (1),  Ensembl(GRCz11):ENSDARG00000033999 (2)
GENE EXPRESSION
All Expression Data: 87 figures from 55 publications
Directly Submitted Expression Data: 3 figures (4 images) from Kudoh et al., 2001 [ibd5061]
  6 figures (61 images) from Thisse et al., 2001 [cb24]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
rw716 Point Mutation Unknown Premature Stop ENU
sa1738 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cyp26a1 N/A 9
    MO2-cyp26a1 N/A 1
    MO3-cyp26a1 N/A 2
    MO4-cyp26a1 N/A 6
    MO5-cyp26a1 N/A 6
    DISEASE ASSOCIATED WITH cyp26a1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cyp26a1 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    holoprosencephaly cyp26a1rw716/rw716 standard conditions Gongal et al., 2008
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to vitamin A (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function retinoic acid 4-hydroxylase activity (more)
    GO Terms (all 34)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR017972 Cytochrome P450, conserved site
    Family IPR001128 Cytochrome P450
    Family IPR002401 Cytochrome P450, E-class, group I
    Homologous_superfamily IPR036396 Cytochrome P450 superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cyp26a1-201 (1)    Ensembl 1830
    cyp26a1-202 (1)    Ensembl 835
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-cyp26a1 polyclonal IgG Rabbit IHC AnaSpec
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cyp26a1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-83cyp26a1-gata2a:EGFP) cyp26a1gata2a EGFP Danio rerio 1 1
    Tg(-195cyp26a1:EGFP) cyp26a1 EGFP Danio rerio 1 1
    Tg(-222cyp26a1-gata2a:EGFP) cyp26a1gata2a EGFP Danio rerio 0 1
    Tg(-310cyp26a1-gata2a:EGFP) cyp26a1gata2a EGFP Danio rerio 1 1
    Tg(cyp26a1-RARE_mut:EYFP) cyp26a1 EYFP Danio rerio 3 2
    Tg(cyp26a1:EYFP) cyp26a1 EYFP Danio rerio 2 6
    Tg(hsp70l:cyp26a1) hsp70l cyp26a1 Danio rerio 1 6
    Tg2(-83cyp26a1-gata2a:EGFP) cyp26a1gata2a EGFP Danio rerio 1 1
    Tg2(-222cyp26a1-gata2a:EGFP) cyp26a1gata2a EGFP Danio rerio 2 1
    MARKER RELATIONSHIPS
    cyp26a1 Contained in: [BAC] DKEY-185B14 (1) (order this)
    cyp26a1 Encodes: [EST] cb24 (1) (order this), fb81e05 (1) (order this), ibd5061 (1)
    [cDNA] MGC:63750 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131146 (1) 1848 nt
    Genomic GenBank:BX323992 (1) 153572 nt
    Select Tool
    Polypeptide UniProtKB:P79739 (1) 492 aa
    Sequence Information (all 18)
    ORTHOLOGY for cyp26a1 ( Chr: 12 )
    CITATIONS (155)