Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-980526-41
Gene Name: sonic hedgehog b
Gene Symbol: shhb
Previous Names: twh, twhh, tiggy winkle hedgehog
Nomenclature History
GENE EXPRESSION
All Expression Data: 44 figures from 33 publications
Directly Submitted Expression Data: 7 figures (30 images) from Thisse et al., 2005 [eu390]
Wild-type Stages, Structures: Blastula:256-cell (2.5h-2.75h) to Adult (90d-730d, breeding adult)
  axis, diencephalon, endoderm, floor plate (all 18) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: la023573Tg, la028783Tg
Knockdown reagents: MO1-shhb (1), MO2-shhb (1), MO3-shhb (1), MO4-shhb (1)
PHENOTYPE
Data: 2 figures from 2 publications
Observed in: blood circulation, odontogenesis, somite

Phenotype of Human Orthologue OMIM Phenotype ID
Holoprosencephaly-3 142945
Microphthalmia with coloboma 5 611638
Schizencephaly 269160
Single median maxillary central incisor 147250
GENE ONTOLOGY
Ontology GO Term
Biological Process embryonic neurocranium morphogenesis (more)
Cellular Component extracellular region (more)
Molecular Function hydrolase activity (more)
GO Terms (all 18)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000320 (1)
  • InterPro:IPR001657 (1)
  • InterPro:IPR001767 (1)
  • InterPro:IPR003586 (1)
  • InterPro:IPR003587 (1)
  • InterPro:IPR009045 (1)
  • Pfam:PF01079 (1)
  • Pfam:PF01085 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA shhb-001 (1) 2019
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM shhb
    Et(shhb:GAL4TA4,UAS:mCherry), Et(shhb:KalTA4,UAS-E1b:mCherry), Tg(-5.2shhb:GFP), Tg(shhb:GAL4TA4,5xUAS:mRFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    shhb Contained in: [BAC] DKEY-265A7 (1)
    shhb Encodes: [EST] eu390 (1)
    [cDNA] MGC:101003 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131199 (1) 1990 bp
    Genomic GenBank:BX510360 (1) 213323 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q6DBX7 (1) 416 aa
    Sequence Clusters UniGene:75752 (1)
    Sequence Information (all 16)
    OTHER shhb GENE PAGES
  • Gene:30444 (1)
  • VEGA:OTTDARG00000018411 (1)
  • Ensembl(Zv9):ENSDARG00000038867 (1)
  • MAPPING INFORMATION
    Chr: 2 Details View Map: Merged   Individual Panels
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish shhb 2  
    Human SHH 7 (7q36)
  • OMIM:600725
  • Gene:6469
  • Mouse Shh 5 ( 14.39 cM)
  • MGI:98297
  • Gene:20423
  • CITATIONS (116)