UniProt ID: Q90419
FUNCTION: Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes.
SUBCELLULAR LOCATION: Tiggy-winkle hedgehog protein N-product: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Extracellular side {ECO:0000250}. Note=The N-terminal peptide remains associated with the cell surface. {ECO:0000250}.
SUBCELLULAR LOCATION: Tiggy-winkle hedgehog protein C-product: Secreted, extracellular space {ECO:0000250}. Note=The C-terminal peptide diffuses from the cell. {ECO:0000250}.
TISSUE SPECIFICITY: Expressed in the ventral midline of the neural tube and brain. In the developing brain, expression occurs in domains that include a discrete region in the floor of the diencephalon. Not detected in the notochord or developing fin bud.
PTM: The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N- terminal fragment (N-product). This covalent modification appears to play an essential role in restricting the spatial distribution of the protein activity to the cell surface. The N-product is the active species in both local and long-range signaling, whereas the C-product has no signaling activity (By similarity). {ECO:0000250}.
SIMILARITY: Belongs to the hedgehog family. {ECO:0000305}.
UniProt ID: Q6DBX7
FUNCTION: Intercellular signal essential for a variety of patterning events during development. {ECO:0000256|RuleBase:RU280812}.
SIMILARITY: Belongs to the hedgehog family. {ECO:0000256|RuleBase:RU280812}.
UniProt ID: A0A0B5JJZ7
FUNCTION: Intercellular signal essential for a variety of patterning events during development. {ECO:0000256|RuleBase:RU280812}.
SIMILARITY: Belongs to the hedgehog family. {ECO:0000256|RuleBase:RU280812}.
This information was provided by UniProt through a collaboration with ZFIN. (1)