Gene
lmo7a
- ID
- ZDB-GENE-030219-74
- Name
- LIM domain 7a
- Symbol
- lmo7a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type deubiquitinase activity and metal ion binding activity. Predicted to act upstream of or within regulation of cell adhesion and regulation of signaling. Is expressed in several structures, including brain; digestive system; eye; immature eye; and pericardial region. Orthologous to human LMO7 (LIM domain 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa13371 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17775 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21468 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa25424 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa27385 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34620 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38736 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45354 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45355 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Calponin homology domain | CH domain superfamily | Domain of unknown function DUF4757 | LIM domain only protein 7 | PDZ domain | PDZ domain 6 | PDZ superfamily | Smooth muscle protein/calponin | Zinc finger, LIM-type |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QJM0
|
1398 | |||||||||
|
UniProtKB:A0A8M9PS20
|
1661 | |||||||||
|
UniProtKB:A0A8M9Q4J8
|
1868 | |||||||||
|
UniProtKB:A0A8M9PS15
|
1874 | |||||||||
|
UniProtKB:A0A8M9Q4K1
|
1648 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-57A22 | ZFIN Curated Data | |
| Encodes | EST | fc03h03 | ||
| Encodes | EST | ibd5155 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128231 (1) | 6323 nt | ||
| Genomic | GenBank:CR536604 (1) | 217381 nt | ||
| Polypeptide | UniProtKB:A0A8M9QJL3 (1) | 1893 aa |
- Li, Y.F., Cheng, T., Zhang, Y.J., Fu, X.X., Mo, J., Zhao, G.Q., Xue, M.G., Zhuo, D.H., Xing, Y.Y., Huang, Y., Sun, X.Z., Wang, D., Liu, X., Dong, Y., Zhu, X.S., He, F., Ma, J., Chen, D., Jin, X., Xu, P.F. (2022) Mycn regulates intestinal development through ribosomal biogenesis in a zebrafish model of Feingold syndrome 1. PLoS Biology. 20:e3001856
- Gomes, G., do Amaral, M.J., Bagri, K.M., Vasconcellos, L.M., Almeida, M.D.S., Alvares, L.E., Mermelstein, C. (2021) New Findings on LMO7 Transcripts, Proteins and Regulatory Regions in Human and Vertebrate Model Organisms and the Intracellular Distribution in Skeletal Muscle Cells. International Journal of Molecular Sciences. 22(23):
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Takeuchi, M., Yamaguchi, S., Sakakibara, M., Hayashi, T., Matsuda, K., Hara, Y., Tanegashima, C., Shimizu, T., Kuraku, S., Hibi, M. (2017) Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. The Journal of comparative neurology. 525(7):1558-1585
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Ott, E.B., van den Akker, N.M., Sakalis, P.A., Gittenberger-de Groot, A.C., Te Velthuis, A.J., and Bagowski, C.P. (2008) The lim domain only protein 7 is important in zebrafish heart development. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(12):3940-3952
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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