ZFIN

ZFIN ID: ZDB-GENE-010202-1

ZFIN ID: ZDB-GENE-010202-1

CITATIONS (68 total)

Gene Name:	mitogen-activated protein kinase 8b
Gene Symbol:	mapk8b

Shao, G.J., Wang, X.L., Wei, M.L., Ren, D.L., Hu, B. (2023) DUSP2 deletion with CRISPR/Cas9 promotes Mauthner cell axonal regeneration at the early stage of zebrafish. Neural regeneration research. 18:577-581

Zhou, C., Chen, J., Liu, K., Maharajan, K., Zhang, Y., Hou, L., Li, J., Mi, M., Xia, Q. (2023) Isoalantolactone protects against ethanol-induced gastric ulcer via alleviating inflammation through regulation of PI3K-Akt signaling pathway and Th17 cell differentiation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 160:114315114315

Derrick, C.J., Santos-Ledo, A., Eley, L., Henderson, D.J., Chaudhry, B. (2022) Sequential action of jnk genes establishes the embryonic left-right axis. Development (Cambridge, England). 149(9):

Wang, S., Bao, J., Li, J., Li, W., Tian, M., Qiu, C., Pang, F., Li, X., Yang, J., Hu, Y., Wang, S., Jin, H. (2022) Fraxinellone Induces Hepatotoxicity in Zebrafish through Oxidative Stress and the Transporters Pathway. Molecules. 27(9):

Wohlfart, D.P., Lou, B., Middel, C.S., Morgenstern, J., Fleming, T., Sticht, C., Hausser, I., Hell, R., Hammes, H.P., Szendrödi, J., Nawroth, P.P., Kroll, J. (2022) Accumulation of acetaldehyde in aldh2.1^-/- zebrafish causes increased retinal angiogenesis and impaired glucose metabolism. Redox Biology. 50:102249

Kuil, L.E., MacKenzie, K.C., Tang, C.S., Windster, J.D., Le, T.L., Karim, A., de Graaf, B.M., van der Helm, R., van Bever, Y., Sloots, C.E.J., Meeussen, C., Tibboel, D., de Klein, A., Wijnen, R.M.H., Amiel, J., Lyonnet, S., Garcia-Barcelo, M.M., Tam, P.K.H., Alves, M.M., Brooks, A.S., Hofstra, R.M.W., Brosens, E. (2021) Size matters: Large copy number losses in Hirschsprung disease patients reveal genes involved in enteric nervous system development. PLoS Genetics. 17:e1009698

Sharma, S., Rana, A.K., Sharma, A., Singh, D. (2021) Inhibition of Mammalian Target of Rapamycin Attenuates Recurrent Seizures Associated Cardiac Damage in a Zebrafish Kindling Model of Chronic Epilepsy. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 17(1-2):334-349

Zhang, Y., Cai, Y., Zhang, S.R., Li, C.Y., Jiang, L.L., Wei, P., He, M.F. (2021) Mechanism of hepatotoxicity of first-line tyrosine kinase inhibitors: gefitinib and afatinib. Toxicology letters. 343:1-10

Qin, J., Ru, S., Wang, W., Hao, L., Ru, Y., Wang, J., Zhang, X. (2020) Long-term bisphenol S exposure aggravates non-alcoholic fatty liver by regulating lipid metabolism and inducing endoplasmic reticulum stress response with activation of unfolded protein response in male zebrafish. Environmental pollution (Barking, Essex : 1987). 263:114535

Saddala, M.S., Lennikov, A., Bouras, A., Huang, H. (2020) RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio. BMC Genomics. 21:132

Santos-Ledo, A., Washer, S., Dhanaseelan, T., Eley, L., Alqatani, A., Chrystal, P.W., Papoutsi, T., Henderson, D.J., Chaudhry, B. (2020) Alternative splicing of jnk1a in zebrafish determines first heart field ventricular cardiomyocyte numbers through modulation of hand2 expression. PLoS Genetics. 16:e1008782

Zhang, D., Lin, W., Liu, Y., Guo, H., Wang, L., Yang, L., Li, L., Li, D., Tang, R. (2020) Chronic Microcystin-LR Exposure Induces Abnormal Lipid Metabolism via Endoplasmic Reticulum Stress in Male Zebrafish. toxins. 12(2):

Zhao, Y., Wang, H.L., Li, T.T., Yang, F., Tzeng, C.M. (2020) Baicalin Ameliorates Dexamethasone-Induced Osteoporosis by Regulation of the RANK/RANKL/OPG Signaling Pathway. Drug design, development and therapy. 14:195-206

Lin, W., Guo, H., Wang, L., Zhang, D., Wu, X., Li, L., Qiu, Y., Yang, L., Li, D., Tang, R. (2019) Waterborne microcystin-LR exposure induced chronic inflammatory response via MyD88-dependent toll-like receptor signaling pathway in male zebrafish. The Science of the total environment. 702:134969

Quan, Y., Gong, L., He, J., Zhou, Y., Liu, M., Cao, Z., Li, Y., Peng, C. (2019) Aloe emodin induces hepatotoxicity by activating NF-κB inflammatory pathway and P53 apoptosis pathway in zebrafish. Toxicology letters. 306:66-79

Li, J.J., Zhang, Y., Han, L.W., Tian, Q.P., He, Q.X., Wang, X.M., Sun, C., Han, J., Liu, K.C. (2018) Tenacissoside H exerts an anti-inflammatory effect by regulating the nf-κb and p38 pathways in zebrafish. Fish & shellfish immunology. 83:205-212

Shi, W.J., Jiang, Y.X., Huang, G.Y., Zhao, J.L., Zhang, J.N., Liu, Y.S., Xie, L., Ying, G.G. (2018) Dydrogesterone causes male bias and accelerates sperm maturation in zebrafish (Danio rerio). Environmental science & technology. 52(15):8903-8911

Zhao, S., Liu, Y., Wang, F., Xu, D., Xie, P. (2018) N-acetylcysteine protects against microcystin-LR-induced endoplasmic reticulum stress and germ cell apoptosis in zebrafish testes. Chemosphere. 204:463-473

Gao, Q., Zhang, J., Wang, X., Liu, Y., He, R., Liu, X., Wang, F., Feng, J., Yang, D., Wang, Z., Meng, A., Yan, X. (2017) The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis. Nature communications. 8:15279

Hu, Y.R., Ma, H., Zou, Z.Y., He, K., Xiao, Y.B., Wang, Y., Feng, M., Ye, X.L., Li, X.G. (2017) Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 85:313-322

Yin, J., Wang, A.P., Li, W.F., Shi, R., Jin, H.T., Wei, J.F. (2017) Sensitive biomarkers identification for differentiating Cd and Pb induced toxicity on zebrafish embryos. Environmental Toxicology and Pharmacology. 56:340-349

Zhang, C.Y., Yin, H.M., Wang, H., Su, D., Xia, Y., Yan, L.F., Fang, B., Liu, W., Wang, Y.M., Gu, A.H., Zhou, Y. (2017) Transforming growth factor-β1 regulates the nascent hematopoietic stem cell niche by promoting gluconeogenesis. Leukemia. 32(2):479-491

Cai, C., Lin, J., Sun, S., He, Y. (2016) JNK Inhibition Inhibits Lateral Line Neuromast Hair Cell Development. Frontiers in Cellular Neuroscience. 10:19

Chen, J., Tanguay, R.L., Xiao, Y., Haggard, D.E., Ge, X., Jia, Y., Zheng, Y., Dong, Q., Huang, C., Lin, K. (2016) TBBPA exposure during a sensitive developmental window produces neurobehavioral changes in larval zebrafish. Environmental pollution (Barking, Essex : 1987). 216:53-63

Li, L., Huang, T., Tian, C., Xiao, Y., Kou, S., Zhou, X., Liu, S., Ye, X., Li, X. (2016) Thedefensive effect of phellodendrine against AAPH-induced oxidative stress throughregulating the AKT/NF-κB pathway in zebrafish embryos. Life sciences. 157:97-106

Qi, M., Dang, Y., Xu, Q., Yu, L., Liu, C., Yuan, Y., Wang, J. (2016) Microcystin-LR induced developmental toxicity and apoptosis in zebrafish (Danio rerio) larvae by activation of ER stress response. Chemosphere. 157:166-173

Wang, Q., Liu, S., Hu, D., Wang, Z., Wang, L., Wu, T., Wu, Z., Mohan, C., Peng, A. (2016) Identification of apoptosis and macrophage migration events in paraquat-induced oxidative stress using a zebrafish model. Life sciences. 157:116-24

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Shen, L., Zhu, J., Chen, F., Lin, W., Cai, J., Zhong, J., Zhong, H. (2015) RUNX1-Evi-1 fusion gene inhibited differentiation and apoptosis in myelopoiesis: an in vivo study. BMC cancer. 15:970

Yang, S., Liu, S., Ren, Z., Jiao, X., and Qin, S. (2014) Induction of oxidative stress and related transcriptional effects of perfluorononanoic acid using an in vivo assessment. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 160:60-65

Tiedke, J., Cubuk, C., and Burmester, T. (2013) Environmental acidification triggers oxidative stress and enhances globin expression in zebrafish gills. Biochemical and Biophysical Research Communications. 441(3):624-9

Xiao, Y., Zhou, Y., Xiong, Z., Zou, L., Jiang, M., Luo, Z., Wen, S., Liu, W., Liu, S., and Li, W. (2013) Involvement of JNK in the Embryonic Development and Organogenesis in Zebrafish. Marine biotechnology (New York, N.Y.). 15(6):716-25

Stengel, R., Rivera-Milla, E., Sahoo, N., Ebert, C., Bollig, F., Heinemann, S.H., Schonherr, R., and Englert, C. (2012) Kcnh1 voltage-gated potassium channels are essential for early zebrafish development. The Journal of biological chemistry. 287(42):35565-35575

Nguyen, A.T., Emelyanov, A., Koh, C.H., Spitsbergen, J.M., Lam, S.H., Mathavan, S., Parinov, S., and Gong, Z. (2011) A high level of liver-specific expression of oncogenic Kras^V12 drives robust liver tumorigenesis in transgenic zebrafish. Disease models & mechanisms. 4(6):801-13

Li, Y.H., Chen, M.H., Gong, H.Y., Hu, S.Y., Li, Y.W., Lin, G.H., Lin, C.C., Liu, W., and Wu, J.L. (2010) Progranulin A-mediated MET signaling is essential for liver morphogenesis in zebrafish. The Journal of biological chemistry. 285(52):41001-41009

Seo, J., Asaoka, Y., Nagai, Y., Hirayama, J., Yamasaki, T., Namae, M., Ohata, S., Shimizu, N., Negishi, T., Kitagawa, D., Kondoh, H., Furutani-Seiki, M., Penninger, J.M., Katada, T., and Nishina, H. (2010) Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation. Journal of cellular biochemistry. 110(4):1022-1037

Shi, X., and Zhou, B. (2010) The Role of Nrf2 and MAPK Pathways in PFOS-induced Oxidative Stress in Zebrafish Embryos. Toxicological sciences : an official journal of the Society of Toxicology. 115(2):391-400

Zhang, Y., Bai, X.T., Zhu, K.Y., Jin, Y., Deng, M., Le, H.Y., Fu, Y.F., Chen, Y., Zhu, J., Look, A.T., Kanki, J., Chen, Z., Chen, S.J., and Liu, T.X. (2008) In Vivo Interstitial Migration of Primitive Macrophages Mediated by JNK-Matrix Metalloproteinase 13 Signaling in Response to Acute Injury. Journal of immunology (Baltimore, Md. : 1950). 181(3):2155-2164

Rui, Y., Xu, Z., Xiong, B., Cao, Y., Lin, S., Zhang, M., Chan, S.C., Luo, W., Han, Y., Lu, Z., Ye, Z., Zhou, H.M., Han, J., Meng, A., and Lin, S.C. (2007) A beta-Catenin-Independent Dorsalization Pathway Activated by Axin/JNK Signaling and Antagonized by Aida. Developmental Cell. 13(2):268-282

Amali, A.A., Rekha, R.D., Lin, C.J., Wang, W.L., Gong, H.Y., Her, G.M., and Wu, J.L. (2006) Thioacetamide induced liver damage in zebrafish embryo as a disease model for steatohepatitis. Journal of Biomedical Science. 13(2):225-232

Krens, S.F., He, S., Spaink, H.P., and Snaar-Jagalska, B.E. (2006) Characterization and expression patterns of the MAPK family in zebrafish. Gene expression patterns : GEP. 6(8):1019-1026

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Fujii, R., Yamashita, S., Hibi, M., and Hirano, T. (2000) Asymmetric p38 activation in zebrafish: Its possible role in symmetric and synchronous cleavage. The Journal of cell biology. 150(6):1335-1347

Additional Citations (25):

ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2022) Automatic Gene Ontology annotation based on Rhea mapping. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) UniProt ID Load from Ensembl. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

ZFIN Staff (2016) Automated addition of links from ZFIN gene pages to SignaFish. Automated Data Submission.

UniProt curators (2015) Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features.. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

GOA, HGNC, AgBase and UniProtKB curators (2007) Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity. ZFIN Direct Data Submission.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

Thisse, B., Thisse, C. (2004) Fast Release Clones: A High Throughput Expression Analysis. ZFIN Direct Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2003) Computational Sequence to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2003) Gene Ontology Annotation Through Association of Enzyme Commission numbers with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.