ZFIN ID: ZDB-GENE-010202-1
Gene Name: mitogen-activated protein kinase 8b
Gene Symbol: mapk8b    Nomenclature History

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Previous Names: jnk1 (1), JNK (1), mapk8, jnk1a-1 (1), zgc:112379

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have JUN kinase activity. Involved in JNK cascade and determination of dorsal identity. Predicted to localize to cytoplasm; nucleus; and synapse. Is expressed in brain; gut; and pectoral fin. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; colorectal adenoma; rectal benign neoplasm; and type 2 diabetes mellitus. Orthologous to human MAPK8 (mitogen-activated protein kinase 8).
Genome Resources: Alliance (1),  Gene:65236 (1),  Ensembl(GRCz11):ENSDARG00000009870 (2)
GENE EXPRESSION
All Expression Data: 10 figures from 7 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:112379]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa24900 Point Mutation Unknown Premature Stop ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-mapk8b N/A 2
MO2-mapk8b N/A 1
DISEASE ASSOCIATED WITH mapk8b HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH mapk8b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process determination of dorsal identity (more)
Cellular Component synapse (more)
Molecular Function ATP binding (more)
GO Terms (all 21)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA mapk8b-201 (1)    Ensembl 2059
mapk8b-203 (1)    Ensembl 1287
mapk8b-204 (1)    Ensembl 1029
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
SignaFish
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM mapk8b No data available
MARKER RELATIONSHIPS
mapk8b Contained in: [BAC] DKEY-191M6 (1) (order this)
mapk8b Encodes: [cDNA] MGC:112379 (1), MGC:191766 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131721 (1) 2108 nt
Genomic GenBank:CR774192 (1) 146133 nt
Select Tool
Polypeptide UniProtKB:Q9DGD9 (1) 384 aa
Sequence Information (all 23)
ORTHOLOGY for mapk8b ( Chr: 12 )
CITATIONS (51)